VERDOUX, Helene

doi:10.1080/19585969.2025.2449833

Bordeaux population health [BPH]

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Article de revue

Ce document a été publié dans

Dialogues in Clinical Neuroscience. 2025-01-10, vol. 27, n° 1, p. 1-12

Résumé en anglais

Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms. Observational studies confirm the persisting high rate of antipsychotic OLU prescription in two out of three youths and 30-60% of adults using antipsychotics. Increasing rates of low-dose quetiapine prescriptions for anxiety or sleep symptoms are paradigmatic of the current public health concern regarding antipsychotic OLU. Such prescriptions receive impetus from industry-funded marketing strategies and prescribers' feeling of innocuousness, with a resulting underestimation of the risk of adverse drug reactions (ADR). However, antipsychotic OLU should be neither trivialised nor demonised since it may be the only therapeutic option in persons with resistant psychiatric disorders or serious ADR with labelled drugs. To reduce the populational impact of antipsychotic OLU, it is necessary to better control the influence of the pharmaceutical industry regarding newly marketed drugs and to better inform prescribers and users about the risks associated with OLU prescribing.< Réduire

Mots clés en anglais

Antipsychotic

Marketing

Metabolic

Off-Label Use

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https://oskar-bordeaux.fr/handle/20.500.12278/204840

DOI

http://dx.doi.org/10.1080/19585969.2025.2449833

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Antipsychotic off-label use in the 21st century: An enduring public health concern

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Résumé en anglais

Mots clés en anglais

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