Purpose : There is limited evidence in the literature demonstrating the usage of infracyanine green (IFCG) in angiography imaging. We performed a prospective clinical study establishing the clinical usefulness of IFCG with fundus imaging to visualize retinal and choroidal vasculature. Methods : A prospective clinical study was conducted at an investigational site in Bordeaux, France that uses the IFCG dye for diagnostic angiography. The subject population was comprised of 11 patients with vitreoretinal and/or choroidal disease, in which angiography was medically indicated. Early, mid, and late phase IFCG angiography (IFCGA) images were captured using a prototype CLARUS™ 700 (ZEISS, Dublin, CA). The acquired images were graded by an independent vitreoretinal specialist using a preset image quality grading scale of 1 to 5, with 1 representing poor image quality and 5 being excellent quality. Results : A total of forty-three IFCGA images captured by the device were sent to the grader; all images were found to be of acceptable or excellent image quality and provided sufficient information for clinical judgement and decision-making (grade ≥3). Representative images from early phase (Figure 1) and late-mid phase (Figure 2) IFCGA clearly show choroidal vasculature, microaneurysms, and some areas of blockage. Conclusions : This study demonstrates the ability of the device to image the posterior segment of the eye using infracyanine green as the injectable dye. IFCG is an iodine-free cyanine dye with similar pharmacological properties to indocyanine green (ICG). Both dyes can be used in angiography imaging to provide visualization of the retinal and choroidal vasculature. While ICG is used exclusively across the US, ophthalmologists in other parts of the world, such as France, also use the IFCG dye for purposes of angiography. To our knowledge, there is limited clinical evidence to-date showcasing the use of IFCGA. The results of our study show that IFCGA images demonstrate good clinical utility across a number of vitreoretinal and choroidal conditions.Read less <