HERVÉ, Perrine; BRINGAUD, Frédéric; RIVIÈRE, Loïc

doi:10.1016/j.pt.2025.01.002

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HERVÉ, Perrine
Microbiologie Fondamentale et Pathogénicité [MFP]

BRINGAUD, Frédéric

Microbiologie Fondamentale et Pathogénicité [MFP]

RIVIÈRE, Loïc
Microbiologie Fondamentale et Pathogénicité [MFP]

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Trends in parasitology. 2025-01-27

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Trypanosoma equiperdum is the etiological agent of dourine, a disease specific to equids (horses, mules, donkeys), and is transmitted through coitus. The parasite emerged from Trypanosoma brucei through the deletion of parts of its kinetoplast DNA, which is essential for the transmission of T. brucei by tsetse flies and completion of its lifecycle. This phenomenon allowed a simplification of the lifecycle of T. equiperdum, which now solely exists as a replicative tissue form. Consequently, without the need of a vector which is restricted to sub-Saharan Africa, the parasite has extended its geographical distribution and is endemic in regions of Asia, Africa, the Middle East, and Eastern Europe. However, difficulties in the diagnosis of T. equiperdum limits accurate data on its prevalence. Finally, the pathogenesis mechanisms of dourine remain largely unknown.< Leer menos

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Trypanosoma equiperdum

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Trypanosoma equiperdum.

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