Disk-shaped compact tension test for fracture analysis on pharmaceutical tablets

GIRARDOT, Jeremie; KOPP, Jean-Benoit; CROQUELOIS, Benjamin; TCHORELOFF, Pierre; MOREL, Stephane; MAZEL, Vincent

doi:10.1016/j.powtec.2022.118016

Institut de Mécanique et d'Ingénierie [I2M]

KOPP, Jean-Benoit

Institut de Mécanique et d'Ingénierie [I2M]

CROQUELOIS, Benjamin

Université de Bordeaux [UB]
Institut de Mécanique et d'Ingénierie [I2M]

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Article de revue

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Powder Technology. 2023-01-01, vol. 413, p. 118016

Resumen en inglés

Pharmaceutical tablets must meet a number of requirements and among them, the mechanical strength plays an important role. The diametral compression test is generally used to evaluate it but can generate unstable failures. Thanks to load–unload cycles applied to the tablets subjected to a DCT test, it was shown that the concept of equivalent linear elastic fracture mechanics usually, can be successfully applied to the Mode I fracture behavior. Within this framework, the equivalent elastic crack growth resistance, commonly called resistance curve (R-curve), of the studied material was obtained and revealed the development of a Fracture Process Zone (FPZ) which is symptomatic of a quasi-brittle behavior. Moreover, the cyclic loading applied during the fracture test revealed the existence of a second dissipative mechanism leading to residual crack opening which seems to be mainly caused by friction phenomenon in the FPZ.< Leer menos

Palabras clave en inglés

DCT

Pharmaceutical tablet

Quasi-brittle fracture

Energy release rate

Fracture process zone

L.E.F.M. equivalent

R-curve

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204548

DOI

http://dx.doi.org/10.1016/j.powtec.2022.118016

Proyecto ANR

Clivage en compression pharmaceutique - ANR-17-CE08-0015

Centros de investigación

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295

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