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Tumor fraction-based prognostic tool for cancer patients referred to early phase clinical trials
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Article de revue
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npj Precision Oncology. 2024-10-07, vol. 8, n° 1, p. 227
Resumen en inglés
Selecting patients for phase I cancer trials is crucial to ensure a sufficient life expectancy. Frail patients, better suited for palliative care, should not be exposed to new drugs with minimal benefit. Enrolling patients ...Leer más >
Selecting patients for phase I cancer trials is crucial to ensure a sufficient life expectancy. Frail patients, better suited for palliative care, should not be exposed to new drugs with minimal benefit. Enrolling patients at high risk of early death can jeopardize the study. Our analysis of two large precision medicine studies used tumor fraction from ctDNA to develop a predictive model, demonstrating notable predictive accuracy and aiding in patient selection.< Leer menos
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