Afficher la notice abrégée

Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

dc.rights.licenseopen
hal.structure.identifierSynthèse organique [E5 – IC2MP équipe 5] [OrgaSynth]
dc.contributor.authorDELATOUCHE, R.
hal.structure.identifierUniversité de Nantes [UN]
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorDENIS, I.
hal.structure.identifierSynthèse organique [E5 – IC2MP équipe 5] [OrgaSynth]
dc.contributor.authorGRINDA, M.
hal.structure.identifierSynthèse organique [E5 – IC2MP équipe 5] [OrgaSynth]
dc.contributor.authorEL BAHHAJ, F.
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
hal.structure.identifierUniversité de Nantes [UN]
dc.contributor.authorBAUCHER, E.
hal.structure.identifierTHEME 1A
dc.contributor.authorCOLLETTE, F.
hal.structure.identifierTHEME 1A
dc.contributor.authorHÉROGUEZ, V.
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
hal.structure.identifierUniversité de Nantes [UN]
dc.contributor.authorGREGOIRE, M.
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
hal.structure.identifierUniversité de Nantes [UN]
dc.contributor.authorBLANQUART, C.
hal.structure.identifierSynthèse organique [E5 – IC2MP équipe 5] [OrgaSynth]
dc.contributor.authorBERTRAND, P.
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn0939-6411
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20314
dc.description.abstractEnThe aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase inhibitors. HDACi are an important class of molecules belonging to the epigenetic modulators used for innovative cancer strategies. The behavior of these prodrugs was determined by a bioluminescence resonance energy transfer assay in living tumor cells. This work demonstrated that this innovative type of clickable prodrugs entered cancer cells and showed restored anti proliferative properties attributed to the effective release of the HDAC inhibitors. A correlation between kinetic studies, dose responses, and biological activities was obtained, making such clickable prodrugs good candidates for new strategies in epigenetic-oriented anticancer therapies
dc.language.isoen
dc.publisherElsevier
dc.title.enDesign of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ejpb.2013.03.006
dc.subject.halChimie/Catalyse
dc.subject.halChimie/Chimie organique
dc.subject.halChimie/Autre
bordeaux.journalEuropean Journal of Pharmaceutics and Biopharmaceutics
bordeaux.page862-872 B
bordeaux.volume85
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue3
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01006764
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01006764v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Pharmaceutics%20and%20Biopharmaceutics&rft.date=2013&rft.volume=85&rft.issue=3&rft.spage=862-872%20B&rft.epage=862-872%20B&rft.eissn=0939-6411&rft.issn=0939-6411&rft.au=DELATOUCHE,%20R.&DENIS,%20I.&GRINDA,%20M.&EL%20BAHHAJ,%20F.&BAUCHER,%20E.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée