This study presents a high-resolution multi-proxy investigation of sediment core MD03-2601 and documents major glacier oscillations and deep water activity during the Holocene in the Adélie Land region, East Antarctica. A comparison with surface ocean conditions reveals synchronous changes of glaciers, sea ice and deep water formation at Milankovitch and sub-Milankovitch time scales. We report (1) a deglaciation of the Adélie Land continental shelf from 11 to 8.5 cal ka BP, which occurred in two phases of effective glacier grounding-line retreat at 10.6 and 9 cal ka BP, associated with active deep water formation; (2) a rapid glacier and sea ice readvance centred around 7.7 cal ka BP; and (3) five rapid expansions of the glacier–sea ice systems, during the Mid to Late Holocene, associated to a long-term increase of deep water formation. At Milankovich time scales, we show that the precessionnal component of insolation at high and low latitudes explains the major trend of the glacier–sea ice–ocean system throughout the Holocene, in the Adélie Land region. In addition, the orbitally-forced seasonality seems to control the coastal deep water formation via the sea ice–ocean coupling, which could lead to opposite patterns between north and south high latitudes during the Mid to Late Holocene. At sub-Milankovitch time scales, there are eight events of glacier–sea ice retreat and expansion that occurred during atmospheric cooling events over East Antarctica. Comparisons of our results with other peri-Antarctic records and model simulations from high southern latitudes may suggest that our interpretation on glacier–sea ice–ocean interactions and their Holocene evolutions reflect a more global Antarctic Holocene pattern.Read less <