LEGROS, Camille; DE PAUW-GILLET, Marie-Claire; TAM, Kam Chiu; LECOMMANDOUX, Sebastien; TATON, Daniel

doi:10.1016/j.eurpolymj.2014.08.026

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LEGROS, Camille
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratory of Mammalian Cell Culture [GIGA-R]
Institute for Nanotechnology [Waterloo]

DE PAUW-GILLET, Marie-Claire
Laboratory of Mammalian Cell Culture [GIGA-R]

TAM, Kam Chiu
Institute for Nanotechnology [Waterloo]

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European Polymer Journal. 2015, vol. 62, p. 322-330

Elsevier

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Protected and non-protected homopolymers and related statistical copolymers based on poly(2-oxazoline) were synthesized by cationic ring-opening (co)polymerization, using a protected aldehyde 2-oxazoline monomer, namely, 2-[3-(1,3)-dioxolan-2-ylpropyl]-2-oxazoline (DPOx). The (co)polymer precursors were subsequently used as reactive platforms enabling the synthesis of miscellaneous derivatives, including graft and crosslinked copoly(2-oxazoline)s. Aldehyde-functional (co)polymers were first reacted with mono- or bi-functional amino- and hydrazido-containing reagents, forming grafted copolymers or chemically cross-linked networks, respectively. The latter compound consisting of hydrazone-type linkages formed hydrogels that could be slowly degraded at physiological pH over 3 days, but be readily cleaved in a more acidic environment (pH = 3). Aldehyde-containing (co)polymers were also found to be subjected to an intermolecular self-aldolization reaction under acidic conditions, leading to branchings and ultimately to the formation of dense 3D-networks.< Leer menos

Palabras clave en inglés

2-ETHYL-2-OXAZOLINE

WELL

RELEASE

HYDROGELS

POLYMERS

CHAIN TRANSFER

CLICK CHEMISTRY

POLY(ETHYLENE GLYCOL)

Aldehyde

Hydrogel

Poly(2-oxazoline)

Post-functionalization modification

Aldolization

RING-OPENING POLYMERIZATION

LIVING POLYMERIZATION

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Aldehyde-functional copolymers based on poly(2-oxazoline) for post-polymerization modification

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