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Synthesis, self-assembly, and degradation of amphiphilic triblock copolymers with fully photodegradable hydrophobic blocks

dc.rights.licenseopen
dc.contributor.authorMCINTOSH, Trevor J.
dc.contributor.authorNAZEMI, Ali
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.contributor.authorGILLIES, Elizabeth R.
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2015
dc.identifier.issn0008-4042
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20263
dc.description.abstractEnThe development of stimuli-responsive materials is of significant interest for many applications including drug delivery, medical imaging, sensors, and microfluidic devices. Among the available stimuli, light is particularly attractive as it can be applied with high spatial and temporal resolution. We describe here the synthesis of amphiphilic triblock copolymers composed of poly(ethylene glycol) and a hydrophobic block containing o-nitrobenzyl esters throughout the backbone using copper-catalyzed azide-alkyne cycloaddition chemistry. These materials were designed to have a high weight fraction of the hydrophobic block to favour nonmicellar aggregates. The self-assembly in water was studied using nanoprecipitation and the resulting assemblies were characterized by dynamic light scattering and transmission electron microscopy. Under optimized conditions, it was possible to prepare polymer vesicles, commonly referred to as polymersomes, with diameters of approximately 100 nm. The degradation of these materials in response to UV light was studied by spectroscopy, light scattering, and electron microscopy, demonstrating that the vesicles were broken down. These results suggest the potential of these materials for applications such as encapsulation and release.
dc.language.isoen
dc.publisherNRC Research Press
dc.subject.enTRIGGERED RELEASE
dc.subject.enDRUG-DELIVERY
dc.subject.enDESIGN
dc.subject.enphotodegradable
dc.subject.enstimuli responsive
dc.subject.envesicles
dc.subject.enpolymersomes
dc.subject.enself-assembly
dc.subject.enNANOPOROUS THIN-FILMS
dc.subject.enDIBLOCK COPOLYMERS
dc.subject.enCLICK POLYMERIZATION
dc.subject.enRESPONSIVE POLYMERS
dc.subject.enNANOPARTICLES
dc.subject.enHYDROGELS
dc.subject.enMICELLES
dc.title.enSynthesis, self-assembly, and degradation of amphiphilic triblock copolymers with fully photodegradable hydrophobic blocks
dc.typeArticle de revue
dc.identifier.doi10.1139/cjc-2014-0263
dc.subject.halChimie/Polymères
bordeaux.journalCanadian Journal of Chemistry
bordeaux.page126-133
bordeaux.volume93
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01361871
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01361871v1
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