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Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Institute for Nanotechnology [Waterloo] | |
| dc.contributor.author | LEGROS, Camille | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | WIROTIUS, Anne-Laure | |
| hal.structure.identifier | Laboratory of Mammalian Cell Culture [GIGA-R] | |
| dc.contributor.author | DE PAUW-GILLET, Marie-Claire | |
| hal.structure.identifier | Institute for Nanotechnology [Waterloo] | |
| dc.contributor.author | TAM, Kam Chiu | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | TATON, Daniel | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20261 | |
| dc.description.abstractEn | Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 mu g/mL) and that no specific interaction with bovine serum albumin was observed. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | BIOMEDICAL APPLICATIONS | |
| dc.subject.en | BLOCK-COPOLYMERS | |
| dc.subject.en | AGGREGATION BEHAVIOR | |
| dc.subject.en | POLY(2-ETHYL-2-OXAZOLINE) | |
| dc.subject.en | POLY(ETHYLENE GLYCOL) | |
| dc.subject.en | GENE DELIVERY | |
| dc.subject.en | IN-VITRO | |
| dc.subject.en | DRUG-DELIVERY | |
| dc.subject.en | PROTEIN ADSORPTION | |
| dc.subject.en | POLYMERIC NANOPARTICLES | |
| dc.title.en | Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/bm501393q | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 183-191 | |
| bordeaux.volume | 16 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01361917 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01361917v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2015&rft.volume=16&rft.issue=1&rft.spage=183-191&rft.epage=183-191&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=LEGROS,%20Camille&WIROTIUS,%20Anne-Laure&DE%20PAUW-GILLET,%20Marie-Claire&TAM,%20Kam%20Chiu&TATON,%20Daniel&rft.genre=article |
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