KRAMER, Jessica R.; PETITDEMANGE, Rosine; BATAILLE, Laure; BATHANY, Katell; WIROTIUS, Anne-Laure; GARBAY, Bertrand; DEMING, Timothy J.; GARANGER, Elisabeth; LECOMMANDOUX, Sebastien

doi:10.1021/acsmacrolett.5b00651

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KRAMER, Jessica R.
Dept of Chemistry and Biochemistry, University of California, Los Angeles [UCLA]
Univ Calif Los Angeles, Dept Bioengn

PETITDEMANGE, Rosine
Laboratoire de Chimie des Polymères Organiques [LCPO]

BATAILLE, Laure
Laboratoire de Chimie des Polymères Organiques [LCPO]

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ACS Macro Letters. 2015, vol. 4, n° 11, p. 1283-1286

Washington, D.C : American Chemical Society

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Tuning the lower critical solution temperature (LCST) of temperature-responsive recombinant elastin-like polypeptides has usually been achieved by designing different protein sequences, in terms of amino acid composition and length, implying tedious molecular cloning steps. In the present work, we have explored the chemoselective alkylation of methionine as an easy means to modify elastin repeat side chains and easily modulate the LCST of the polypeptides. Such a versatile synthetic method shall practically be exploited to modulate any properties of recombinant polymers.< Leer menos

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Quantitative Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides as a Versatile Tool to Tune Their Properties

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