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Selective Tuning of Elastin-like Polypeptide Properties via Methionine Oxidation

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorPETITDEMANGE, Rosine
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBATAILLE, Laure
dc.contributor.authorBATHANY, Katell
dc.contributor.authorDIERYCK, Wilfrid
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARBAY, Bertrand
IDREF: 033777551
hal.structure.identifierUniv Calif Los Angeles, Dept Bioengn
hal.structure.identifierDept of Chemistry and Biochemistry, University of California, Los Angeles [UCLA]
dc.contributor.authorDEMING, Timothy J.
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20144
dc.description.abstractEnWe have designed and prepared a recombinant elastin-like polypeptide (ELP) containing precisely positioned methionine residues, and performed the selective and complete oxidation of its methionine thioether groups to both sulfoxide and sulfone derivatives. Since these oxidation reactions substantially increase methionine residue polarity, they were found to be a useful means to precisely adjust the temperature responsive behavior of ELPs in aqueous solutions. In particular, lower critical solution temperatures were found to be elevated in oxidized sample solutions, but were not eliminated. These transition temperatures were found to be further tunable by the use of solvents containing different Hofmeister salts. Overall, the ability to selectively and fully oxidize methionine residues in ELPs proved to be a convenient postmodification strategy for tuning their transition temperatures in aqueous media.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enElastin-like polypeptides
dc.subject.enMethionine oxidation
dc.title.enSelective Tuning of Elastin-like Polypeptide Properties via Methionine Oxidation
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.biomac.6b01696
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
bordeaux.journalBiomacromolecules
bordeaux.page544-550
bordeaux.volume18
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01449294
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01449294v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2017&rft.volume=18&rft.issue=2&rft.spage=544-550&rft.epage=544-550&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=PETITDEMANGE,%20Rosine&GARANGER,%20Elisabeth&BATAILLE,%20Laure&BATHANY,%20Katell&DIERYCK,%20Wilfrid&rft.genre=article


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