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Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierInstitut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
dc.contributor.authorIBRAHIMOVA, Vusala
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDENISOV, Sergey A.
hal.structure.identifierUnité de Pharmacologie Cellulaire et Moléculaire [Brussels]
dc.contributor.authorVANVARENBERG, Kevin
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorVERWILST, Peter
hal.structure.identifierUnité de Pharmacologie Cellulaire et Moléculaire [Brussels]
dc.contributor.authorPRÉAT, Véronique
hal.structure.identifierInstitut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]
dc.contributor.authorGUIGNER, Jean-Michel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorMCCLENAGHAN, Nathan
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierInstitut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences [IMCN]
dc.contributor.authorFUSTIN, Charles-André
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn2040-3364
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20103
dc.description.abstractEnLocalization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitro tests on two cancer cell lines were performed. This study aims at providing guidelines for the optimization of the synthetic design of therapeutic nanomedicines with minimal amounts of photosensitive molecules.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enPhotosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy
dc.typeArticle de revue
dc.identifier.doi10.1039/C7NR04403H
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
bordeaux.journalNanoscale
bordeaux.page11180-11186
bordeaux.volume9
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue31
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01579522
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01579522v1
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