DASKALOV, Asen

doi:10.1016/j.isci.2023.106793

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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iScience. 2023-05, vol. 26, n° 6

Resumen en inglés

Investigation of fungal biology has been frequently motivated by the fact that many fungal species are important plant and animal pathogens. Such efforts have contributed significantly toward our understanding of fungal pathogenic lifestyles (virulence factors and strategies) and the interplay with host immune systems. In parallel, work on fungal allorecognition systems leading to the characterization of fungal regulated cell death determinants and pathways, has been instrumental for the emergent concept of fungal immunity. The uncovered evolutionary trans-kingdom parallels between fungal regulated cell death pathways and innate immune systems incite us to reflect further on the concept of a fungal immune system. Here, I briefly review key findings that have shaped the fungal immunity paradigm, providing a perspective on what I consider its most glaring knowledge gaps. Undertaking to fill such gaps would establish firmly the fungal immune system inside the broader field of comparative immunology. © 2023 The Author(s)< Leer menos

Palabras clave en inglés

Cell biology; Immunology; Microbiology

URI

https://oskar-bordeaux.fr/handle/20.500.12278/200641

DOI

http://dx.doi.org/10.1016/j.isci.2023.106793

Centros de investigación

ImmunoConcEpT - UMR 5164

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Emergence of the fungal immune system

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Resumen en inglés

Palabras clave en inglés

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DOI

Centros de investigación