Afficher la notice abrégée

Drug releasing nanoplatforms activated by alternating magnetic fields

dc.rights.licenseopen
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorMERTZ, Damien
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierObservatoire des Micro et Nano Technologies [OMNT - UMS 2920]
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorBEGIN-COLIN, Sylvie
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn0304-4165
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19995
dc.description.abstractEnThe use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo.This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials".Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.language.isoen
dc.publisherElsevier
dc.subject.meshmagneto-thermal effect
dc.subject.meshmagnetic carrier
dc.subject.meshtriggered drug release
dc.subject.meshdrug releasing magnetic nanoplatforms
dc.subject.meshin vitro drug release experiment
dc.subject.meshin vivo tumor regression
dc.title.enDrug releasing nanoplatforms activated by alternating magnetic fields
dc.typeArticle de revue
dc.identifier.doi10.1016/j.bbagen.2017.02.025
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halChimie/Chimie inorganique
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
bordeaux.journalBiochimica et Biophysica Acta (BBA) - General Subjects
bordeaux.page1617-1641
bordeaux.volume1861
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01476632
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01476632v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimica%20et%20Biophysica%20Acta%20(BBA)%20-%20General%20Subjects&rft.date=2017&rft.volume=1861&rft.issue=6&rft.spage=1617-1641&rft.epage=1617-1641&rft.eissn=0304-4165&rft.issn=0304-4165&rft.au=MERTZ,%20Damien&SANDRE,%20Olivier&BEGIN-COLIN,%20Sylvie&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée