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Magnetic field triggered drug release from polymersomes for cancer therapeutics

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorDE OLIVEIRA, Hugo
dc.contributor.authorPEREZ-ANDRES, Encarnacion
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.contributor.authorBERRA, Edurne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn0168-3659
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19994
dc.description.abstractEnLocal and temporal control of drug release has for long been a main focus in the development of novel drug carriers. Polymersomes, which can load both hydrophilic and hydrophobic species and, at the same time, be tailored to respond to a desired stimulus, have drawn much attention over the last decade. Here we describe polymersomes able to encapsulate up to 6% (w/w) of doxorubicin (DOX) together with 30% (w/w) of superparamagnetic iron oxide nanoparticles (USPIO; gamma-Fe2O3). Upon internalization in HeLa cells and when a high frequency AC magnetic field (14 mT at 750 kHz) was applied, the developed delivery system elicited an 18% increase in cell toxicity, associated with augmented DOX release kinetics. In order to ensure that the observed cytotoxicity arose from the increased doxorubicin release and not from a pure magnetic hyperthermia effect, polymersomes loaded with magnetic nanoparticles alone were also tested. In this case, no increased toxicity was observed. We hypothesize that the magnetic field is inducing a very local hyperthermia effect at the level of the polymersome membrane, increasing drug release. This approach opens new perspectives in the development of smart delivery systems able to release drug upon demand and therefore, improving treatment control. (C) 2013 Elsevier B. V. All rights reserved.
dc.language.isoen
dc.publisherElsevier
dc.subject.enTheranostic
dc.subject.enCancer therapy
dc.subject.enControlled drug delivery
dc.subject.enPolymersomes
dc.subject.enMagnetic field
dc.subject.enHyperthermia
dc.title.enMagnetic field triggered drug release from polymersomes for cancer therapeutics
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jconrel.2013.01.013
dc.subject.halChimie/Polymères
bordeaux.journalJournal of Controlled Release
bordeaux.page165-170
bordeaux.volume169
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue3
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00926568
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00926568v1
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