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Hybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: impact of the nanostructure on the relaxometric properties

dc.rights.licenseopen
hal.structure.identifierUniversità degli Studi di Milano = University of Milan [UNIMI]
dc.contributor.authorAROSIO, Paolo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorTHEVENOT, Julie
dc.contributor.authorORLANDO, Tomas
hal.structure.identifierUniversità degli Studi di Milano = University of Milan [UNIMI]
dc.contributor.authorORSINI, Francesco
dc.contributor.authorCORTI, Maurizio
hal.structure.identifierAlma Mater Studiorum Università di Bologna = University of Bologna [UNIBO]
dc.contributor.authorMARIANI, Manuel
dc.contributor.authorBORDONALI, Lorenzo
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
dc.contributor.authorINNOCENTI, Claudia
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
dc.contributor.authorSANGREGORIO, Claudio
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierUniversità degli Studi di Milano = University of Milan [UNIMI]
dc.contributor.authorLASCIALFARI, Alessandro
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn2050-750X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19987
dc.description.abstractEnMagnetic resonance imaging (MRI) is at the forefront of non-invasive medical imaging techniques. It provides good spatial and temporal resolution that can be further improved by the use of contrast agents (CAs), providing a valuable tool for diagnostic purposes. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are attractive MRI contrast agents due to their negative (T-2) contrast enhancement capability and biocompatibility. Clusters of USPIOs with polymer material are of particular interest since they can sustain additional functionalities like drug delivery and targeting. Aiming to establish a relationship between the morphology of the clusters and their efficacy as MRI contrast agents (relaxometric properties), we prepared - using three different maghemite (gamma-Fe2O3) USPIO diameters - a series of hybrid copolymer/iron oxide CAs presenting two different geometries (micellar or vesicular). The NMR relaxometry profiles confirmed the nature of the physical mechanisms inducing the increase of nuclear relaxation rates at low (magnetic anisotropy) and high (Curie relaxation) magnetic fields. A heuristic model, first proposed by Roch, Muller, Gillis, and Brooks, allowed the fitting of the whole longitudinal relaxivity r(1)(v) profile, for samples with different magnetic core sizes. We show that both types of clusters exhibit transverse relaxivity (r(2)) values comparable to or higher than those of common contrast agents, over the whole tested frequency range. Moreover, in-depth analysis revealed substantially a linear relationship between r(2) and the number of encapsulated USPIOs divided by the diameter of the clusters (N-USPIO/D-H), for each USPIO size. The cluster structure (i.e. micelle or vesicle) appeared to have a mild influence on the transverse relaxivity value. Indeed, the r(2) value was mainly governed by the individual size of the USPIOs, correlated with both the cluster external diameter and the magnetic material volume fraction.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enFERUMOXIDES
dc.subject.enWATER PROTON
dc.subject.enMAGNETIC NANOPARTICLES
dc.subject.enCONTRAST ENHANCEMENT
dc.subject.enFERUMOXTRAN
dc.subject.enPOLYMER MICELLES
dc.subject.enREORIENTATION
dc.subject.enSUPERPARAMAGNETIC PARTICLES
dc.subject.enPROTON RELAXATION ENHANCEMENT
dc.subject.enLIGHT SCATTERING
dc.subject.enPOLYMER VESICLES
dc.title.enHybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: impact of the nanostructure on the relaxometric properties
dc.typeArticle de revue
dc.identifier.doi10.1039/c3tb00429e
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Chimie théorique et/ou physique
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.description.sponsorshipEuropeFP7 CP-IP 213631-2 NANOTHER
bordeaux.journalJournal of materials chemistry‎ B
bordeaux.page5317-5328
bordeaux.volume1
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue39
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00959556
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00959556v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20materials%20chemistry%E2%80%8E%20B&rft.date=2013&rft.volume=1&rft.issue=39&rft.spage=5317-5328&rft.epage=5317-5328&rft.eissn=2050-750X&rft.issn=2050-750X&rft.au=AROSIO,%20Paolo&THEVENOT,%20Julie&ORLANDO,%20Tomas&ORSINI,%20Francesco&CORTI,%20Maurizio&rft.genre=article


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