Proteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital
GERET, Florence
Géographie de l'environnement [GEODE]
Institut national universitaire Champollion [Albi] [INUC]
< Réduire
Géographie de l'environnement [GEODE]
Institut national universitaire Champollion [Albi] [INUC]
Langue
en
Article de revue
Ce document a été publié dans
Environmental Science and Pollution Research. 2016-03, vol. 23, n° 6, p. 5046-5055
Springer Verlag
Résumé en anglais
The increase use of pharmaceutical compounds in veterinary practice and human population results in the ubiquitous presence of these compounds in aquatic ecosystems. Because pharmaceuticals are highly bioactive, there is ...Lire la suite >
The increase use of pharmaceutical compounds in veterinary practice and human population results in the ubiquitous presence of these compounds in aquatic ecosystems. Because pharmaceuticals are highly bioactive, there is concern about their toxicological effects in aquatic organisms. Therefore, the aim of this study was to assess the effects of an effluent from a psychiatric hospital (containing a complex mixture of 25 pharmaceutical compounds from eleven therapeutic classes) on the freshwater clam Corbicula fluminea using a proteomic approach. The exposure of C. fluminea to this complex effluent containing anxiolytics, analgesics, lipid regulators, beta blockers, antidepressants, antiepileptics, antihistamines, antihypertensives, antiplatelets and antiarrhythmics induced protein changes after 1 day of exposure in clam gills and digestive gland more evident in the digestive gland. These changes included increase in the abundance of proteins associated with structural (actin and tubulin), cellular functions (calreticulin, proliferating cell nuclear antigen (PCNA), T complex protein 1 (TCP1)) and metabolism (aldehyde dehydrogenase (ALDH), alcohol dehydrogenase, 6 phosphogluconate dehydrogenase). Results from this study indicate that calreticulin, PCNA, ALDH and alcohol dehydrogenase in the digestive gland and T complex protein 1 (TCP1)) and 6 phosphogluconate dehydrogenase in the gills represent useful biomarkers for the ecotoxicological characterization of psychiatric hospital effluents in this species.< Réduire
Mots clés en anglais
Corbicula fluminea
Proteomics
Hospital effluent
Pharmaceutical compounds