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Synthetic glycopolypeptides: synthesis and self-assembly of poly([gamma]-benzyl-l-glutamate)-glycosylated dendron hybrids

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorPEYRET, Ariane
dc.contributor.authorTRANT, John F.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorFERJI, Khalid
dc.contributor.authorJAIN, Namrata
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.contributor.authorGILLIES, Elisabeth R.
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2015
dc.identifier.issn1759-9954
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19964
dc.description.abstractEnNano-assemblies prepared from glycosylated macromolecules are promising systems for modulating or mimicking the interactions between natural carbohydrates and their receptors. In the current work, polyester dendrons bearing focal point alkynes and peripheral C-linked [small alpha]-galactose moieties were synthesized and coupled to helical poly([gamma]-benzyl-l-glutamate) (PBLG) to afford synthetic linear-dendritic glycopolypeptides. Both the dendrimer generation and the length of the PBLG were varied to provide a small library of amphiphiles with hydrophilic mass fractions ranging from 0.07 to 0.54. The self-assembly of the copolymers in water using a solvent exchange method was optimized and studied in detail. While the linear-dendritic copolymers composed of lower generation dendrons tended to aggregate, a copolymer composed of a 4th generation galactose-functionalized dendron and PBLG with a degree of polymerization of 28 formed micellar nano-assemblies whose size could be tuned by varying the self-assembly process. Overall, this study provides new insights into the effects of polymer architecture on self-assembly properties, while at the same time introducing a new platform for the preparation of bioactive nanoparticles.
dc.language.isoen
dc.publisherRoyal Society of Chemistry - RSC
dc.title.enSynthetic glycopolypeptides: synthesis and self-assembly of poly([gamma]-benzyl-l-glutamate)-glycosylated dendron hybrids
dc.typeArticle de revue
dc.identifier.doi10.1039/C5PY01060H
dc.subject.halChimie/Chimie de coordination
bordeaux.journalPolymer Chemistry
bordeaux.page7902-7912
bordeaux.volume6
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue45
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01920328
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01920328v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2015&rft.volume=6&rft.issue=45&rft.spage=7902-7912&rft.epage=7902-7912&rft.eissn=1759-9954&rft.issn=1759-9954&rft.au=PEYRET,%20Ariane&TRANT,%20John%20F.&BONDUELLE,%20Colin&FERJI,%20Khalid&JAIN,%20Namrata&rft.genre=article


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