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Prefrontal circuits encode both general danger and specific threat representations

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARTIN-FERNANDEZ, Mario
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMENEGOLLA, Ana Paula
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLOPEZ-FERNANDEZ, Guillem
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorWINKE, Nanci
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJERCOG, Daniel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKIM, Ha-Rang
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGIRARD, Delphine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDEJEAN, Cyril
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
dc.date.accessioned2024-05-06T09:59:21Z
dc.date.available2024-05-06T09:59:21Z
dc.date.issued2023-12
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199649
dc.description.abstractEnBehavioral adaptation to potential threats requires both a global representation of danger to prepare the organism to react in a timely manner but also the identification of specific threatening situations to select the appropriate behavioral responses. The prefrontal cortex is known to control threat-related behaviors, yet it is unknown whether it encodes global defensive states and/or the identity of specific threatening encounters. Using a new behavioral paradigm that exposes mice to different threatening situations, we show that the dorsomedial prefrontal cortex (dmPFC) encodes a general representation of danger while simultaneously encoding a specific neuronal representation of each threat. Importantly, the global representation of danger persisted in error trials that instead lacked specific threat identity representations. Consistently, optogenetic prefrontal inhibition impaired overall behavioral performance and discrimination of different threatening situations without any bias toward active or passive behaviors. Together, these data indicate that the prefrontal cortex encodes both a global representation of danger and specific representations of threat identity to control the selection of defensive behaviors. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008en_US
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enMice
dc.subject.enNeurons* / physiology
dc.subject.enOptogenetics
dc.subject.enPrefrontal Cortex* / physiology
dc.title.enPrefrontal circuits encode both general danger and specific threat representations
dc.title.alternativeNat Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41593-023-01472-8en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37904042en_US
bordeaux.journalNature Neuroscienceen_US
bordeaux.page2147-2157en_US
bordeaux.volume26en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamCircuits neuronaux des apprentissages associatifsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04569370
hal.version1
hal.date.transferred2024-05-06T09:59:23Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Neuroscience&rft.date=2023-12&rft.volume=26&rft.issue=12&rft.spage=2147-2157&rft.epage=2147-2157&rft.au=MARTIN-FERNANDEZ,%20Mario&MENEGOLLA,%20Ana%20Paula&LOPEZ-FERNANDEZ,%20Guillem&WINKE,%20Nanci&JERCOG,%20Daniel&rft.genre=article


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