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Polymersomes in "Gelly" Polymersomes: Toward Structural Cell Mimicry

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorMARGUET, Maïté
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2012
dc.date.issued2012
dc.identifier.issn0743-7463
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19937
dc.description.abstractEnWe demonstrate here the formation of compartmentalized polymersomes with an internal "gelly" cavity using an original and versatile process. Nanosize polymersomes of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA), formed by a solvent displacement method are encapsulated with a rough "cytoplasm mimic" in giant polymersomes of poly(butadiene)-b-poly(ethylene oxide) PB-b-PEO by emulsion-centrifugation. Such a system constitutes a first step toward the challenge of structural cell mimicry with both "organelles" and "cytoplasm mimics". The structure is demonstrated with fluorescence labeling and confocal microscopy imaging with movies featuring the motion of the inner nanosize polymersomes in larger vesicles. Without "cytoplasm mimic", the motion was confirmed to be Brownian by particle tracking analysis. The inner nanosize polymersomes motion was blocked in the presence of alginate, but only hindered in the presence of dextran. With the use of such high molecular weight and concentrated polysaccharides, the crowded internal volume of cells, responsible for the so-called "macromolecular crowding" effect influencing every intracellular macromolecular association, seems to be efficiently mimicked. This study constitutes major progress in the field of structural biomimicry and will certainly enable the rise of new, highly interesting properties in the field of high-added value soft matter.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enMACROMOLECULAR CROWDING
dc.subject.enPROTEIN MIMIC
dc.subject.enALGINATE SOLUTION
dc.subject.enDRUG DELIVERY
dc.subject.enLIPOSOME
dc.subject.enGIANT UNILAMELLAR VESICLES
dc.subject.enEMULSION-CENTRIFUGATION
dc.subject.enNANOPARTICLE TRACKING
dc.subject.enNANOREACTOR
dc.subject.enDRUG DELIVERY SYSTEMS
dc.title.enPolymersomes in "Gelly" Polymersomes: Toward Structural Cell Mimicry
dc.typeArticle de revue
dc.identifier.doi10.1021/la204018w
dc.subject.halChimie/Polymères
bordeaux.journalLangmuir
bordeaux.page2035-2043
bordeaux.volume28
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue4
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00744114
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00744114v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2012&rft.volume=28&rft.issue=4&rft.spage=2035-2043&rft.epage=2035-2043&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=MARGUET,%20Ma%C3%AFt%C3%A9&SANDRE,%20Olivier&LECOMMANDOUX,%20Sebastien&rft.genre=article


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