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Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

dc.rights.licenseopenen_US
dc.contributor.authorMOAL, Bertrand
dc.contributor.authorORIEUX, Arthur
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFERTE, Thomas
dc.contributor.authorNEURAZ, Antoine
dc.contributor.authorBRAT, Gabriel A
dc.contributor.authorAVILLACH, Paul
dc.contributor.authorBONZEL, Clara-Lea
dc.contributor.authorCAI, Tianxi
dc.contributor.authorCHO, Kelly
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOSSIN, Sebastien
dc.contributor.authorGRIFFIER, Romain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHANAUER, David A
dc.contributor.authorHAVERKAMP, Christian
dc.contributor.authorHO, Yuk-Lam
dc.contributor.authorHONG, Chuan
dc.contributor.authorHUTCH, Meghan R
dc.contributor.authorKLANN, Jeffrey G
dc.contributor.authorLE, Trang T
dc.contributor.authorLOH, Ne Hooi Will
dc.contributor.authorLUO, Yuan
dc.contributor.authorMAKOUDJOU, Adeline
dc.contributor.authorMORRIS, Michele
dc.contributor.authorMOWERY, Danielle L
dc.contributor.authorOLSON, Karen L
dc.contributor.authorPATEL, Lav P
dc.contributor.authorSAMAYAMUTHU, Malarkodi J
dc.contributor.authorSANZ VIDORRETA, Fernando J
dc.contributor.authorSCHRIVER, Emily R
dc.contributor.authorSCHUBERT, Petra
dc.contributor.authorVERDY, Guillaume
dc.contributor.authorVISWESWARAN, Shyam
dc.contributor.authorWANG, Xuan
dc.contributor.authorWEBER, Griffin M
dc.contributor.authorXIA, Zongqi
dc.contributor.authorYUAN, William
dc.contributor.authorZHANG, Harrison G
dc.contributor.authorZOLLER, Daniela
dc.contributor.authorKOHANE, Isaac S
dc.contributor.authorBOYER, Alexandre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJOUHET, Vianney
dc.date.accessioned2024-04-29T11:46:13Z
dc.date.available2024-04-29T11:46:13Z
dc.date.issued2023-04-05
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199366
dc.description.abstractEnPURPOSE: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. METHODS: A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. RESULTS: Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). CONCLUSION: Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAcute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0266985en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36598895en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee0266985en_US
bordeaux.volume18en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04564226
hal.version2
hal.date.transferred2024-04-30T23:04:05Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2023-04-05&rft.volume=18&rft.issue=1&rft.spage=e0266985&rft.epage=e0266985&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=MOAL,%20Bertrand&ORIEUX,%20Arthur&FERTE,%20Thomas&NEURAZ,%20Antoine&BRAT,%20Gabriel%20A&rft.genre=article


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