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dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBACCOUCH, Rim
dc.contributor.authorSHI, Yarong
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorVERNAY, Emilie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMATHELIE-GUINLET, Marion
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTAIB-MAAMAR, Nada
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorVILLETTE, Sandrine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFEUILLIE, Cecile
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRASCOL, Estelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorNUSS, Philippe
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLECOMTE, Sophie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMOLINARI, Michael
dc.contributor.authorSTANEVA, Galya
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorALVES, Isabel
dc.date.accessioned2024-04-24T10:05:32Z
dc.date.available2024-04-24T10:05:32Z
dc.date.issued2023-02
dc.identifier.issn0005-2736en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199305
dc.description.abstractEnThe lipid composition of cellular membranes and the balance between the different lipid components can be impacted by aging, certain pathologies, specific diets and other factors. This is the case in a subgroup of individuals with psychiatric disorders, such as schizophrenia, where cell membranes of patients have been shown to be deprived in polyunsaturated fatty acids (PUFAs), not only in brain areas where the target receptors are expressed but also in peripheral tissues. This PUFA deprivation thus represents a biomarker of such disorders that might impact not only the interaction of antipsychotic medications with these membranes but also the activation and signaling of the targeted receptors embedded in the lipid membrane. Therefore, it is crucial to understand how PUFAs levels alterations modulate the different physical properties of membranes.In this paper, several biophysical approaches were combined (Laurdan fluorescence spectroscopy, atomic force microscopy, differential scanning calorimetry, molecular modeling) to characterize membrane properties such as fluidity, elasticity and thickness in PUFA-enriched cell membranes and lipid model systems reflecting the PUFA imbalance observed in some diseases. The impact of both the number of unsaturations and their position along the chain on the above properties was investigated. Briefly, data revealed that PUFA presence in membranes increases membrane fluidity, elasticity and flexibility and decreases its thickness and order parameter. Both the level of unsaturation and their position affect these membrane properties.
dc.language.isoENen_US
dc.subject.enpolyunsaturated fatty acids
dc.subject.enlipid membrane physico-chemical properties
dc.subject.enfluidity
dc.subject.enlipid phase transition temperature
dc.subject.enthickness
dc.title.enThe impact of lipid polyunsaturation on the physical and mechanical properties of lipid membranes
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbamem.2022.184084en_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysiqueen_US
bordeaux.journalBiochimica et Biophysica Acta:Biomembranesen_US
bordeaux.page184084en_US
bordeaux.volume1865en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03864167
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimica%20et%20Biophysica%20Acta:Biomembranes&rft.date=2023-02&rft.volume=1865&rft.issue=2&rft.spage=184084&rft.epage=184084&rft.eissn=0005-2736&rft.issn=0005-2736&rft.au=BACCOUCH,%20Rim&SHI,%20Yarong&VERNAY,%20Emilie&MATHELIE-GUINLET,%20Marion&TAIB-MAAMAR,%20Nada&rft.genre=article


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