Nature-inspired synthetic oligourea foldamer channels allow water transport with high salt rejection
YOO, Sung
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
PASCO, Morgane
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
GRELARD, Axelle
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
LOQUET, Antoine
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
GUICHARD, Gilles
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
< Reduce
Institut Européen de Chimie et Biologie [IECB]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Language
EN
Article de revue
This item was published in
Chem. 2023-08, vol. 9, n° 8, p. 2237-2254
English Abstract
Short helical amphipathic oligourea foldamers were designed with distinct hydrophobic and hydrophilic faces. Two of the foldamers (H2OC1 and H2OC2) obtained by solid phase synthesis self-assembled into channel-type ...Read more >
Short helical amphipathic oligourea foldamers were designed with distinct hydrophobic and hydrophilic faces. Two of the foldamers (H2OC1 and H2OC2) obtained by solid phase synthesis self-assembled into channel-type nanostructures that show efficient water permeability across lipid membranes while rejecting ions. A self-assembled quaternary structure with two superhelical scaffolds results in the formation of 4.8 and 6.4 A ˚inner pores that were observed in the crystal packing of H2OC1. Both pores have hydrophilic interior and hydrophobic exterior surfaces. Our findings demonstrate the channel-forming ability of oligourea foldamers in lipid bilayers, and such novel artificial water channels could be beneficial for water purification applications.Read less <
English Keywords
Oligourea foldamers supramolecular assembly artificial water channels desalination water transport stopped flow
Oligourea foldamers
supramolecular assembly
artificial water channels
desalination
water transport
stopped flow