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Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
hal.structure.identifierAlbert-Ludwigs-Universität Freiburg
dc.contributor.authorSPONSEL, Janina
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorGUO, Yubing
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorHAMZAM, Lutfir
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorLAVANANT, Alice
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorPÉREZ-RIVERÓN, Annia
hal.structure.identifierInstitut de Recherche en Infectiologie de Montpellier [IRIM]
dc.contributor.authorPARTIOT, Emma
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMULLER, Quentin
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorROTTURA, Julien
hal.structure.identifierInstitut de Recherche en Infectiologie de Montpellier [IRIM]
dc.contributor.authorGAUDIN, Raphael
hal.structure.identifierHelmholtz Centre for Infection Research [HZI]
hal.structure.identifierUniversity of Saarland / Universität des Saarlandes [Homburg, Germany]
dc.contributor.authorHAUCK, Dirk
hal.structure.identifierHelmholtz Centre for Infection Research [HZI]
hal.structure.identifierUniversity of Saarland / Universität des Saarlandes [Homburg, Germany]
dc.contributor.authorTITZ, Alexander
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorFLACHER, Vincent
hal.structure.identifierAlbert-Ludwigs-Universität Freiburg
dc.contributor.authorRÖMER, Winfried
hal.structure.identifierInstitut de biologie moléculaire et cellulaire [IBMC]
dc.contributor.authorMUELLER, Christopher
dc.date.accessioned2024-04-19T10:26:40Z
dc.date.available2024-04-19T10:26:40Z
dc.date.issued2023
dc.identifier.issn1469-221Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199246
dc.description.abstractEnAbstract Pseudomonas aeruginosa is a Gram‐negative bacterium causing morbidity and mortality in immuno‐compromised humans. It produces a lectin, LecB, that is considered a major virulence factor, however, its impact on the immune system remains incompletely understood. Here we show that LecB binds to endothelial cells in human skin and mice and disrupts the transendothelial passage of leukocytes in vitro . It impairs the migration of dendritic cells into the paracortex of lymph nodes leading to a reduced antigen‐specific T cell response. Under the effect of the lectin, endothelial cells undergo profound cellular changes resulting in endocytosis and degradation of the junctional protein VE‐cadherin, formation of an actin rim, and arrested cell motility. This likely negatively impacts the capacity of endothelial cells to respond to extracellular stimuli and to generate the intercellular gaps for allowing leukocyte diapedesis. A LecB inhibitor can restore dendritic cell migration and T cell activation, underlining the importance of LecB antagonism to reactivate the immune response against P. aeruginosa infection.
dc.description.sponsorshipCaractérisation des déterminants moléculaires impliqués dans la migration cellulaire induite par le virus Zika - ANR-20-CE15-0019en_US
dc.language.isoENen_US
dc.subject.enbacterial lectin
dc.subject.endendritic cells
dc.subject.enlymphatics
dc.subject.enmigration
dc.subject.enskin
dc.title.enPseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration
dc.typeArticle de revueen_US
dc.identifier.doi10.15252/embr.202255971en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Immunité adaptativeen_US
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Immunité innéeen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologieen_US
bordeaux.journalEMBO Reportsen_US
bordeaux.pagee55971en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04261591
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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