RIGOTHIER, Claire; CATROS, Sylvain; BENARD, Antoine; SAMOT, Johan; QUINTIN, Olivier; COMBE, Christian; LARABI, Islam Amine; MASSY, Ziad; ALVAREZ, Jean Claude

doi:10.3390/toxins15110666

Service de Néphrologie-transplantation-dialyse [Bordeaux]
Bioingénierie tissulaire [BIOTIS]

CATROS, Sylvain

Bioingénierie tissulaire [BIOTIS]
CHU de Bordeaux Pellegrin [Bordeaux]

BENARD, Antoine
CHU de Bordeaux Pellegrin [Bordeaux]
Bordeaux population health [BPH]

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Toxins. 2023, vol. 15, n° 11

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Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.< Leer menos

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chronic kidney disease

dental health

saliva

uremic toxins

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https://oskar-bordeaux.fr/handle/20.500.12278/199236

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http://dx.doi.org/10.3390/toxins15110666

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Association between Dental Scores and Saliva Uremic Toxins

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Association between Dental Scores and Saliva Uremic Toxins

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