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Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles

dc.rights.licenseopenen_US
dc.contributor.authorDAVIDSON, Sean M.
dc.contributor.authorBOULANGER, Chantal M.
dc.contributor.authorAIKAWA, Elena
dc.contributor.authorBADIMON, Lina
dc.contributor.authorBARILE, Lucio
dc.contributor.authorBINDER, Christoph J.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRISSON, Alain
dc.contributor.authorBUZAS, Edit
dc.contributor.authorEMANUELI, Costanza
dc.contributor.authorJANSEN, Felix
dc.contributor.authorKATSUR, Miroslava
dc.contributor.authorLACROIX, Romaric
dc.contributor.authorLIM, Sai Kiang
dc.contributor.authorMACKMAN, Nigel
dc.contributor.authorMAYR, Manuel
dc.contributor.authorMENASCHE, Philippe
dc.contributor.authorNIEUWLAND, Rienk
dc.contributor.authorSAHOO, Susmita
dc.contributor.authorTAKOV, Kaloyan
dc.contributor.authorTHUM, Thomas
dc.contributor.authorVADER, Pieter
dc.contributor.authorWAUBEN, Marca H. M.
dc.contributor.authorWITWER, Kenneth
dc.contributor.authorSLUIJTER, Joost P. G.
dc.date.accessioned2024-04-16T09:01:46Z
dc.date.available2024-04-16T09:01:46Z
dc.date.issued2023-01-01
dc.identifier.issn0008-6363en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199078
dc.description.abstractEnExtracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. Two types of EVs of particular interest are exosomes and microvesicles, which have been identified in all tissue and body fluids and carry a variety of molecules including RNAs, proteins, and lipids. EVs have potential for use in the diagnosis and prognosis of cardiovascular diseases and as new therapeutic agents, particularly in the setting of myocardial infarction and heart failure. Despite their promise, technical challenges related to their small size make it challenging to accurately identify and characterize them, and to study EV-mediated processes. Here, we aim to provide the reader with an overview of the techniques and technologies available for the separation and characterization of EVs from different sources. Methods for determining the protein, RNA, and lipid content of EVs are discussed. The aim of this document is to provide guidance on critical methodological issues and highlight key points for consideration for the investigation of EVs in cardiovascular studies.
dc.description.sponsorshipARN non codant d'origine cardiomyocytaire et remodelage cardiaque post-ischémiqueen_US
dc.language.isoENen_US
dc.subject.enCardiovascular diseases
dc.subject.enExosomes
dc.subject.enExtracellular vesicles
dc.subject.enMicro vesicles
dc.subject.enPlasma
dc.title.enMethods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles
dc.title.alternativeCardiovascular Researchen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cvr/cvac031en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalCardiovascular Researchen_US
bordeaux.page45-63en_US
bordeaux.volume119en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cardiovascular%20Research&rft.date=2023-01-01&rft.volume=119&rft.issue=1&rft.spage=45-63&rft.epage=45-63&rft.eissn=0008-6363&rft.issn=0008-6363&rft.au=DAVIDSON,%20Sean%20M.&BOULANGER,%20Chantal%20M.&AIKAWA,%20Elena&BADIMON,%20Lina&BARILE,%20Lucio&rft.genre=article


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