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Sublethal effects of waterborne uranium exposures on the zebrafish brain: transcriptional responses and alterations of the olfactory bulb ultrastructure

dc.rights.licenseopenen_US
dc.contributor.authorLEREBOURS, Adélaïde
dc.contributor.authorLAÏDE LEREBOURS, Adé
dc.contributor.authorVAN DER VEN, Karlijn
dc.contributor.authorVEN, Van Der Karlijn
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOURDINEAUD, Jean-Paul
dc.contributor.authorVEN, Karlijn Van Der
dc.contributor.authorVANDENBROUCK, Tine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorCAMILLERI, Virginie
dc.contributor.authorFLORIANI, Magali
dc.contributor.authorGARNIER-LAPLACE, Jacqueline
dc.contributor.authorADAM-GUILLERMIN, Christelle
dc.date.accessioned2024-04-16T08:13:13Z
dc.date.available2024-04-16T08:13:13Z
dc.date.issued2010-01-01
dc.identifier.issn0013-936Xen_US
dc.identifier.urioai:crossref.org:10.1021/es902550x
dc.identifier.uriftunivantwerpen:oai:ir.anet.ua.ac.be:10067/806410151162165141
dc.identifier.urioai:researchgate.net:41101002
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199071
dc.description.abstractEnThe toxic action modes of uranium (U) in fish are still scarcely known. U is known to modify the acetylcholinesterase activity in the fish brain. To gain further insight into U neurotoxicity in fish, we examined transcriptional responses in the brain of the zebrafish, Danio rerio, exposed to 15 μg L−1 and 100 μg L−1 of waterborne U for 3 and 10 days. In parallel, an ultrastructure analysis of the neuropil of the olfactory bulb, an area in the brain of fish sensitive to metal contamination, was performed after 10 days of U exposure. This combined transcriptomic and histological study is the first report performed in the brain and specifically the olfactory bulb of fish exposed to U. We found that 56 transcripts responded to the metal exposure, and the anatomical structure of the olfactory bulb was damaged. The greatest gene response occurred at the lower U concentration and the numbers of responding genes common to any two U exposures were much smaller than those unique to each exposure. These data showed that the intensity of gene response may not correlate positively with toxicant concentrations according to our experimental design. Instead, different patterns of gene expression are expected for each exposure. Gene responses were categorized into eight functional classes, and the transcriptional responses of genes involved in the olfactory system were significantly affected. Collectively, the data suggest that genes in the olfactory region may be ecologically relevant and sensitive transcriptional biomarkers of U waterborne exposure.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourcebase
dc.sourceresearchgate
dc.title.enSublethal effects of waterborne uranium exposures on the zebrafish brain: transcriptional responses and alterations of the olfactory bulb ultrastructure
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/es902550xen_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEnvironmental Science and Technologyen_US
bordeaux.page1438-1443en_US
bordeaux.volume44en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04547871
hal.version1
hal.date.transferred2024-04-16T08:13:16Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Technology&rft.date=2010-01-01&rft.volume=44&rft.issue=4&rft.spage=1438-1443&rft.epage=1438-1443&rft.eissn=0013-936X&rft.issn=0013-936X&rft.au=LEREBOURS,%20Ade%CC%81lai%CC%88de&LA%C3%8FDE%20LEREBOURS,%20Ad%C3%A9&VAN%20DER%20VEN,%20Karlijn&VEN,%20Van%20Der%20Karlijn&BOURDINEAUD,%20Jean-Paul&rft.genre=article


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