Hybrid polymer/lipid vesicles: fine control of the lipid and polymer distribution in the binary membrane
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
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Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SANDRE, Olivier
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LE MEINS, Jean-Francois
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Soft Matter. 2012, vol. 8, n° 10, p. 2867-2874
Royal Society of Chemistry
Résumé en anglais
Hybrid polymer/lipid giant unilamellar vesicles (GUVs) were developed using lipids of respectively low and high melting transition temperature (DPPC: 1,2-dipalmitoyl-sn-glycero-3 phosphocholine, T-m = 41 degrees C, and ...Lire la suite >
Hybrid polymer/lipid giant unilamellar vesicles (GUVs) were developed using lipids of respectively low and high melting transition temperature (DPPC: 1,2-dipalmitoyl-sn-glycero-3 phosphocholine, T-m = 41 degrees C, and POPC: palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; T-m = -2 degrees C) and a copolymer poly(dimethylsiloxane)-graft-poly(ethylene oxide) (PDMS-g-PEO) well known to self-assemble into vesicular structures. Using epifluorescence microscopy as well as differential scanning calorimetry (DSC), different structures have been identified depending on the molar composition and on the fluid or gel state of the lipid used. The most promising objects are hybrid vesicles with copolymer as the major component, in which lipids are either randomly distributed or present "raft-like'' domains in the polymer-rich membrane. The results are discussed on the basis of the fluidity of the different components and of their respective membrane thicknesses< Réduire
Mots clés en anglais
TRIBLOCK COPOLYMER VESICLES
BLOCK-COPOLYMERS
BIODEGRADABLE POLYMERSOMES
FLUID MEMBRANES
DRUG-DELIVERY
LIPOSOMES
ADHESION
PERMEABILITY
STABILITY
MICELLES
Origine
Importé de halUnités de recherche