SIEPMANN, Juergen; FAHAM, Amina; CLAS, Sophie-Dorothée; BOYD, Ben; JANNIN, Vincent; BERNKOP-SCHNÜRCH, Andreas; ZHAO, Hang; LECOMMANDOUX, Sebastien; EVANS, James; ALLEN, Christine; MERKEL, Olivia; COSTABILE, Gabriella; ALEXANDER, Morgan; WILDMAN, Ricky; ROBERTS, Clive; LEROUX, Jean-Christophe

doi:10.1016/j.ijpharm.2018.12.080

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SIEPMANN, Juergen
Institut National de la Santé et de la Recherche Médicale [INSERM]

FAHAM, Amina
DuPont Health & Nutrition

CLAS, Sophie-Dorothée
PharmaSolv Consulting

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International Journal of Pharmaceutics. 2019, vol. 558, p. 128-142

Elsevier

Résumé en anglais

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Annual Scientific Meeting of the Gattefossé Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.< Réduire

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peptides

gene delivery

polymersomes

liposomes

solid dispersions

self-emulsifying drug delivery systems

sustained release

3D printing

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Lipids and polymers in pharmaceutical technology: lifelong companions

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