Embedding of superparamagnetic iron oxide nanoparticles into membranes of well-defined poly(ethylene oxide)-block-poly(ε-caprolactone) nanoscale magnetovesicles as ultrasensitive MRI probes of membrane bio-degradation
| dc.rights.license | open | |
| dc.contributor.author | HANNECART, Adeline | |
| dc.contributor.author | STANICKI, Dimitri | |
| dc.contributor.author | VANDER ELST, Luce | |
| dc.contributor.author | MULLER, Robert N | |
| hal.structure.identifier | Laboratoire Léon Brillouin [LLB - UMR 12] | |
| hal.structure.identifier | Commissariat à l'énergie atomique et aux énergies alternatives [CEA] | |
| dc.contributor.author | BRÛLET, Annie | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | SANDRE, Olivier | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | SCHATZ, Christophe | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.contributor.author | LAURENT, Sophie | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 2050-750X | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19863 | |
| dc.description.abstractEn | The present study reports the preparation of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) polymer vesicles via a nanoprecipitation method and the loading of two different size hydrophobically coated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (magnetic core size of 4.2 nm and 7.6 nm) into the membrane of these nanovesicles, whose thickness was measured precisely by small angle neutron scattering (SANS). Spherical nano-assemblies with a high USPIO payload and a diameter close to 150 nm were obtained as confirmed by dynamic light scattering (DLS), transmission electron microscopy (TEM) and cryo-TEM. Vesicular structure of these hybrid nano-assemblies was confirmed by multi-angle light scattering (MALS) measurements. Their magnetic properties were evaluated by T1 and T2 measurements (20 and 60 MHz) and by nuclear magnetic relaxation dispersion (NMRD) profiles. The size of USPIO entrapped in the membranes of PEO-b-PCL vesicles has a strong impact on their magnetic properties. It affects both their longitudinal and their transverse relaxivities and thus their magnetic resonance imaging (MRI) sensitivity. Acid-catalyzed hydrolysis of PCL membrane also influences their relaxivities as shown by measurements carried out at pH 7 vs. pH 5. This property was used to monitor the membrane hydrolytic degradation in vitro, as a proof of concept of potential monitoring of a drug delivery by nanomedicines in vivo and non-invasively, by MRI. | |
| dc.description.sponsorship | Magnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017 | |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry | |
| dc.subject.en | Magnetic nanocarriers | |
| dc.subject.en | MRI-guided therapy | |
| dc.subject.en | Acidolysis | |
| dc.subject.en | Polymer vesicles | |
| dc.subject.en | Polymersomes | |
| dc.subject.en | Magnetic nanoparticles MNPs | |
| dc.subject.en | MRI contrast agents | |
| dc.subject.en | Biodegradable polymers | |
| dc.subject.en | Polycaprolactone | |
| dc.title.en | Embedding of superparamagnetic iron oxide nanoparticles into membranes of well-defined poly(ethylene oxide)-block-poly(ε-caprolactone) nanoscale magnetovesicles as ultrasensitive MRI probes of membrane bio-degradation | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1039/C9TB00909D | |
| dc.subject.hal | Chimie/Polymères | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Ingénierie biomédicale | |
| dc.description.sponsorshipEurope | Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy | |
| bordeaux.journal | Journal of materials chemistry B | |
| bordeaux.page | 4692-4705 | |
| bordeaux.volume | 7 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 30 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02164409 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02164409v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20materials%20chemistry%E2%80%8E%20B&rft.date=2019&rft.volume=7&rft.issue=30&rft.spage=4692-4705&rft.epage=4692-4705&rft.eissn=2050-750X&rft.issn=2050-750X&rft.au=HANNECART,%20Adeline&STANICKI,%20Dimitri&VANDER%20ELST,%20Luce&MULLER,%20Robert%20N&BR%C3%9BLET,%20Annie&rft.genre=article |
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