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Auto-degradable and biocompatible superparamagnetic iron oxide nanoparticles/polypeptides colloidal polyion complexes with high density of magnetic material

dc.rights.licenseopen
hal.structure.identifierSouthwest University of Science and Technology [Mianyang] [SWUST]
dc.contributor.authorWANG, Bin
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.contributor.authorWANG, Kunzhou
hal.structure.identifierCollege of Chemistry and Materials Science, Jinan University
dc.contributor.authorSHI, Haishan
hal.structure.identifierSouthwest University of Science and Technology [Mianyang] [SWUST]
dc.contributor.authorXIONG, Kun
hal.structure.identifierChangchun Institute of Applied Chemistry
dc.contributor.authorHUANG, Yu-Bin
hal.structure.identifierJinan University [Guangzhou]
dc.contributor.authorWU, Tingting
hal.structure.identifierSouthwest University of Science and Technology [Mianyang] [SWUST]
dc.contributor.authorYAN, Minhao
hal.structure.identifierSouthwest University of Science and Technology [Mianyang] [SWUST]
dc.contributor.authorCOURTOIS, Jérémie
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2019
dc.identifier.issn0928-4931
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19862
dc.description.abstractEnHypothesis: superparamagnetic iron oxide nanoparticles (SPIONs) are extensively used as building block of colloidal nanocomposites for biomedical applications. Strategies employed to embed them in a biodegradable and biocompatible polymer matrix often fail to achieve a high density of loading which would greatly benefit to applications such as imaging and hyperthermia. In this study, poly(acrylic acid) coated SPION (γ-Fe2O3-PAA) are self-assembled with hydrolysable poly(serine ester) by electrostatic complexation, leading to perfectly defined spherical particles with ultra-high density of magnetic material and an ability to auto-degrade into individual SPION and biocompatible byproducts.Experiments: self-assembly and auto-degradation of γ-Fe2O3-PAA/poly(serine ester) and γ-Fe2O3-PAA/poly(serine ester)-b-PEG colloidal particles are studied by light scattering and microscopy. Colloidal stability in bio-fluids, hyperthermia under alternating magnetic field, cellular uptake, cytotoxicity and degradation of γ-Fe2O3-PAA/poly(serine ester)-b-PEG in living cells are investigated.Findings: a remarkably slow electrostatic complexation leads to dense superparamagnetic γ-Fe2O3-PAA/poly(serine ester)-b-PEG polyion complexes (PICs) with controlled sizes (150 – 500 nm) and times of degradation in aqueous solvents (700 – 5000 h). The material shows good sustainability during hyperthermia, is well taken up by MC3T3 cells and non-cytotoxic. TEM images reveal a mechanism of degradation by “peeling” and fragmentation. In cells, PICs are reduced into individual SPIONs within 72 h.
dc.language.isoen
dc.publisherElsevier
dc.subject.meshSuperparamagnetic iron oxide nanoparticle (SPION)
dc.subject.meshPeptide-based polyester
dc.subject.meshPolyion complex
dc.subject.meshMagnetic hyperthermia
dc.subject.meshElectrostatic complexation
dc.subject.meshBiodegradabilty
dc.title.enAuto-degradable and biocompatible superparamagnetic iron oxide nanoparticles/polypeptides colloidal polyion complexes with high density of magnetic material
dc.typeArticle de revue
dc.identifier.doi10.1016/j.msec.2019.109920
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux
bordeaux.journalMaterials Science and Engineering: C
bordeaux.page109920
bordeaux.volume104
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02167584
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02167584v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Materials%20Science%20and%20Engineering:%20C&rft.date=2019&rft.volume=104&rft.spage=109920&rft.epage=109920&rft.eissn=0928-4931&rft.issn=0928-4931&rft.au=WANG,%20Bin&SANDRE,%20Olivier&WANG,%20Kunzhou&SHI,%20Haishan&XIONG,%20Kun&rft.genre=article


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