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Multifunctional polymersomes for cancer theranostics

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorTHÉVENOT, Julie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorPOURTAU, Line
dc.contributor.authorANDRÉS, Encarnacion
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTHIAUDIÈRE, Eric
dc.contributor.authorBERRA, Edurne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn0168-3659
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19840
dc.description.abstractEnThe concept of personalized medicine is drawing a lot of attention, pointing out the future for medical and pharmaceutical practices, where synthetic nanovectors could be considered as interesting tools. First generation vectors have proved their ability to reduce deleterious side effects, especially in cancer therapy. But the current trend aims at the elaboration of nanovectors that will be able to cross biological barriers, bind to the diseased site, release a drug in a controlled manner and act as an imaging agent for both diagnosis and treatment follow-up [1]. Thanks to their unique features, polymersomes have shown, in a relatively short period of time, their potential as both therapeutic and imaging tools and appear especially suited for the elaboration of multifunctional carriers. Here, we describe the production, characterization and evaluation in vitro and in vivo of a multicomponent, targeted polymersome system, focusing in a bone metastasis model (from breast cancer). Non-toxic, bioresorbable, amphiphilic block copolymer, poly(trimethylene carbonate)-b-poly(γ-benzyl-l-glutamate), forming polymersomes upon self-assembly, was functionalized using a hetero-bifunctional oligo(ethylene glycol) linker allowing the covalent grafting of antibodies targeting the HER2 receptor. A versatile strategy allowed the preparation in two steps of polymersomes loaded with both anticancer drug and magnetic iron oxide nanoparticles [2] and bearing antibodies at their surface. Efficient and selective targeting of HER2 expressing cells was demonstrated with these polymersomes (Fig. 1). They also elicited good properties as contrast agents for MRI and the drug release was triggered under magnetic hyperthermia, showing that these systems are promising tools for theranostic applications.
dc.language.isoen
dc.publisherElsevier
dc.title.enMultifunctional polymersomes for cancer theranostics
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jconrel.2013.08.094
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.description.sponsorshipEuropeIntegration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer
bordeaux.journalJournal of Controlled Release
bordeaux.pagee44-e45
bordeaux.volume172
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02202462
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02202462v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Controlled%20Release&rft.date=2013&rft.volume=172&rft.issue=1&rft.spage=e44-e45&rft.epage=e44-e45&rft.eissn=0168-3659&rft.issn=0168-3659&rft.au=TH%C3%89VENOT,%20Julie&DE%20OLIVEIRA,%20Hugo&SANDRE,%20Olivier&POURTAU,%20Line&ANDR%C3%89S,%20Encarnacion&rft.genre=article


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