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Photon-triggered polymersome rupture under temporal, spatial and spectral control

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorPEYRET, Ariane
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTRON, Arnaud
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBEAUTÉ, Louis
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorRUST, Ruben
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorMCCLENAGHAN, Nathan
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn0168-3659
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19839
dc.description.abstractEnPolymersomes are robust self-assembled vesicular structures that are widely studied in a variety of domains from nanomedicine to artificial cell design [1]. Control over their membrane diffusion properties and structural integrity is crucial for their future development [2]. In particular, a high level of control is mandatory in drug delivery applications where species have to be released at the right place and time. Here, we present a high precision method allowing programmed vesicle rupture with full control in time, space and excitation wavelength for selective cargo-release.We designed an easy and tunable protocol for light-driven specific polymersome rupture controlled in time and space, which combines the advantages of utilizing light as a trigger and the fast release of components from bursting vesicles. Our system is based on laser excitation of hydrophilic dyes loaded in the lumen of distinct giant poly(butadiene)-b-poly(ethylene oxide) polymersomes. Upon excitation, the fast generation of reactive oxygen species leads to an increase of the internal osmotic pressure that can not be compensated fast enough, resulting in subsequent vesicle rupture (Fig. 1). This process allows for a precise and fast release of entrapped species from different compartments. Additionally, such a selective mechanism allows discrimination between two types of vesicles within a group of many and successive triggered release of their content without altering the remaining vesicles. This unique mechanism is shown to selectively rupture polymersomes with high precision, and even to deliver small polymersomes and liposomes.
dc.description.sponsorshipDéveloppement de cellule synthétique comme micro-réacteur pour l'étude de l'activité enzymatique des NO-synthases et la compréhension de leur fonctionnement en conditions physiologiques - ANR-14-CE16-0015
dc.language.isoen
dc.publisherElsevier
dc.subject.entargeted delivery
dc.subject.endiethylstilbestrol
dc.subject.encancer hormone therapy
dc.subject.entriggered rupture
dc.subject.enpolymersomes
dc.subject.encargo-release
dc.subject.enself-assembly
dc.subject.enlight stimulus
dc.subject.enreactive oxygen species
dc.title.enPhoton-triggered polymersome rupture under temporal, spatial and spectral control
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jconrel.2017.03.049
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halPhysique [physics]/Physique [physics]/Optique [physics.optics]
bordeaux.journalJournal of Controlled Release
bordeaux.pagee8-e9
bordeaux.volume259
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02202669
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02202669v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Controlled%20Release&rft.date=2017&rft.volume=259&rft.spage=e8-e9&rft.epage=e8-e9&rft.eissn=0168-3659&rft.issn=0168-3659&rft.au=PEYRET,%20Ariane&IBARBOURE,%20Emmanuel&TRON,%20Arnaud&BEAUTE%CC%81,%20Louis&RUST,%20Ruben&rft.genre=article


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