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Comparative genomics of emerging pathogens in the Candida glabrata clade.

hal.structure.identifierBioinformatics and Genomics Programme
dc.contributor.authorGABALDÓN, Toni
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorMARTIN, Tiphaine
hal.structure.identifierBioinformatics and Genomics Programme
dc.contributor.authorMARCET-HOUBEN, Marina
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorDURRENS, Pascal
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorBOLOTIN-FUKUHARA, Monique
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorLESPINET, Olivier
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorARNAISE, Sylvie
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorBOISNARD, Stéphanie
hal.structure.identifierBioinformatics and Genomics Programme
dc.contributor.authorAGUILETA, Gabriela
hal.structure.identifierImmunité et Infection
dc.contributor.authorATANASOVA, Ralitsa
hal.structure.identifierGénomique (Plate-Forme) - Genomics Platform
dc.contributor.authorBOUCHIER, Christiane
hal.structure.identifierGenoscope - Centre national de séquençage [Evry] [GENOSCOPE]
dc.contributor.authorCOULOUX, Arnaud
hal.structure.identifierGénomique (Plate-Forme) - Genomics Platform
dc.contributor.authorCRENO, Sophie
hal.structure.identifierArchitecture et Réactivité de l'ARN [ARN]
hal.structure.identifierComparative Genomics Group
dc.contributor.authorALMEIDA CRUZ, Jose
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorDEVILLERS, Hugo
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
hal.structure.identifierService de Microbiologie
dc.contributor.authorENACHE-ANGOULVANT, Adela
hal.structure.identifierImmunité et Infection
dc.contributor.authorGUITARD, Juliette
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorJAOUEN, Laure
hal.structure.identifierGénomique (Plate-Forme) - Genomics Platform
dc.contributor.authorMA, Laurence
hal.structure.identifierInstitut de Biologie et de Technologies de Saclay [IBITECS]
dc.contributor.authorMARCK, Christian
hal.structure.identifierMICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
dc.contributor.authorNEUVÉGLISE, Cécile
hal.structure.identifierGenoscope - Centre national de séquençage [Evry] [GENOSCOPE]
dc.contributor.authorPELLETIER, Eric
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorPINARD, Amélie
hal.structure.identifierGenoscope - Centre national de séquençage [Evry] [GENOSCOPE]
dc.contributor.authorPOULAIN, Julie
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorRECOQUILLAY, Julien
hal.structure.identifierArchitecture et Réactivité de l'ARN [ARN]
dc.contributor.authorWESTHOF, Eric
hal.structure.identifierGenoscope - Centre national de séquençage [Evry] [GENOSCOPE]
dc.contributor.authorWINCKER, Patrick
hal.structure.identifierGénétique Moléculaire des Levures
dc.contributor.authorDUJON, Bernard
hal.structure.identifierImmunité et Infection
dc.contributor.authorHENNEQUIN, Christophe
hal.structure.identifierInstitut de génétique et microbiologie [Orsay] [IGM]
dc.contributor.authorFAIRHEAD, Cécile
dc.date.accessioned2024-04-15T09:42:45Z
dc.date.available2024-04-15T09:42:45Z
dc.date.issued2013-09-14
dc.identifier.issn1471-2164
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197706
dc.description.abstractEnBACKGROUND: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C. glabrata being part of the Nakaseomyces, a group more closely related to Saccharomyces cerevisiae. Although C. glabrata was thought to be the only pathogenic Nakaseomyces, two new pathogens have recently been described within this group: C. nivariensis and C. bracarensis. To gain insight into the genomic changes underlying the emergence of virulence, we sequenced the genomes of these two, and three other non-pathogenic Nakaseomyces, and compared them to other sequenced yeasts. RESULTS: Our results indicate that the two new pathogens are more closely related to the non-pathogenic N. delphensis than to C. glabrata. We uncover duplications and accelerated evolution that specifically affected genes in the lineage preceding the group containing N. delphensis and the three pathogens, which may provide clues to the higher propensity of this group to infect humans. Finally, the number of Epa-like adhesins is specifically enriched in the pathogens, particularly in C. glabrata. CONCLUSIONS: Remarkably, some features thought to be the result of adaptation of C. glabrata to a pathogenic lifestyle, are present throughout the Nakaseomyces, indicating these are rather ancient adaptations to other environments. Phylogeny suggests that human pathogenesis evolved several times, independently within the clade. The expansion of the EPA gene family in pathogens establishes an evolutionary link between adhesion and virulence phenotypes. Our analyses thus shed light onto the relationships between virulence and the recent genomic changes that occurred within the Nakaseomyces.Sequence Accession Numbers: Nakaseomyces delphensis: CAPT01000001 to CAPT01000179Candida bracarensis: CAPU01000001 to CAPU01000251Candida nivariensis: CAPV01000001 to CAPV01000123Candida castellii: CAPW01000001 to CAPW01000101Nakaseomyces bacillisporus: CAPX01000001 to CAPX01000186.
dc.language.isoen
dc.publisherBioMed Central
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enCandida glabrata
dc.subject.enFungal pathogens
dc.subject.enNakaseomyces
dc.subject.enYeast genomes
dc.subject.enYeast evolution
dc.subject.enCandida glabrata
dc.subject.enCandida glabrata
dc.subject.enCandida glabrata
dc.title.enComparative genomics of emerging pathogens in the Candida glabrata clade.
dc.typeArticle de revue
dc.identifier.doi10.1186/1471-2164-14-623
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
dc.description.sponsorshipEuropeEvolutionary genomics of long, non-coding RNAs
dc.description.sponsorshipEuropeThe genomic basis of emerging fungal pathogenicity
bordeaux.journalBMC Genomics
bordeaux.page623
bordeaux.volume14
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierinserm-00871184
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-00871184v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Genomics&rft.date=2013-09-14&rft.volume=14&rft.issue=1&rft.spage=623&rft.epage=623&rft.eissn=1471-2164&rft.issn=1471-2164&rft.au=GABALD%C3%93N,%20Toni&MARTIN,%20Tiphaine&MARCET-HOUBEN,%20Marina&DURRENS,%20Pascal&BOLOTIN-FUKUHARA,%20Monique&rft.genre=article


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