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Comparative genomics of Mycoplasma feriruminatoris, a fast-growing pathogen of wild Caprinae

hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierFaculté de Médecine Vétérinaire, Université de Montréal
dc.contributor.authorBABY, Vincent
hal.structure.identifierVetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement [VAS]
dc.contributor.authorAMBROSET, Chloé
hal.structure.identifierVetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement [VAS]
dc.contributor.authorGAURIVAUD, Patrice
hal.structure.identifierSwiss Institute of Bioinformatics [Genève] [SIB]
dc.contributor.authorFALQUET, Laurent
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorBOURY, Christophe
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorGUICHOUX, Erwan
hal.structure.identifierVetsuisse Faculty
dc.contributor.authorJORES, Joerg
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLARTIGUE, Carole
hal.structure.identifierMycoplasmoses animales – UMR [MYCO]
dc.contributor.authorTARDY, Florence
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorSIRAND-PUGNET, Pascal
dc.date.accessioned2024-04-11T10:06:42Z
dc.date.available2024-04-11T10:06:42Z
dc.date.issued2023-10-12
dc.identifier.issn2057-5858
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197559
dc.description.abstractEnMycoplasma feriruminatoris is a fast-growing Mycoplasma species isolated from wild Caprinae and first described in 2013. M. feriruminatoris isolates have been associated with arthritis, kerato conjunctivitis, pneumonia and septicemia, but were also recovered from apparently healthy animals. To better understand what defines this species, we performed a genomic survey on 14 strains collected from free-ranging or zoo-housed animals between 1987 and 2017, mostly in Europe. The average chromosome size of the M. feriruminatoris strains was 1,040±0,024 kbp, with 24 % G+C and 852±31 CDS. The core genome and pan-genome of the M. feriruminatoris species contained 628 and 1312 protein families, respectively. The M. feriruminatoris strains displayed a relatively closed pan-genome, with many features and putative virulence factors shared with species from the M. mycoides cluster, including the MIB-MIP Ig cleavage system, a repertoire of DUF285 surface proteins and a complete biosynthetic pathway for galactan. M. feriruminatoris genomes were found to be mostly syntenic, although repertoires of mobile genetic elements, including Mycoplasma Integrative and Conjugative Elements, insertion sequences, and a single plasmid varied. Phylogenetic- and gene content analyses confirmed that M. feriruminatoris was closer to the M. mycoides cluster than to the ruminant species M. yeatsii and M. putrefaciens . Ancestral genome reconstruction showed that the emergence of the M. feriruminatoris species was associated with the gain of 17 gene families, some of which encode defence enzymes and surface proteins, and the loss of 25 others, some of which are involved in sugar transport and metabolism. This comparative study suggests that the M. mycoides cluster could be extended to include M. feriruminatoris . We also find evidence that the specific organization and structure of the DnaA boxes around the oriC of M. feriruminatoris may contribute to drive the remarkable fast growth of this minimal bacterium.
dc.language.isoen
dc.publisherSociety for General Microbiology
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enM. mycoides cluster
dc.subject.enMycoplasma feriruminatoris
dc.subject.enmobile elements
dc.subject.enmollicutes
dc.subject.enoriC
dc.subject.enpolysaccharide biosynthesis
dc.subject.enruminant pathogen.
dc.title.enComparative genomics of Mycoplasma feriruminatoris, a fast-growing pathogen of wild Caprinae
dc.typeArticle de revue
dc.identifier.doi10.1099/mgen.0.001112
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
bordeaux.journalMicrobial Genomics
bordeaux.volume9
bordeaux.hal.laboratoriesBiologie du Fruit & Pathologie (BFP) - UMR 1332*
bordeaux.issue10
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
bordeaux.peerReviewedoui
hal.identifierhal-04323203
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04323203v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microbial%20Genomics&rft.date=2023-10-12&rft.volume=9&rft.issue=10&rft.eissn=2057-5858&rft.issn=2057-5858&rft.au=BABY,%20Vincent&AMBROSET,%20Chlo%C3%A9&GAURIVAUD,%20Patrice&FALQUET,%20Laurent&BOURY,%20Christophe&rft.genre=article


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