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RAMbo-V project: paving the way for the development of synthetic vaccines against Mycoplasma bovis

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorRIDEAU, Fabien
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorHOGAN, Patrick
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorDERRICHE, M’hamed
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGOURGUES, Geraldine
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorPOT, Gwendoline
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorSIMON, Elisa
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorMAILLARD, Renaud
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorCITTI, C.
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorNOUVEL, Laurent-Xavier
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBEVEN, Laure
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorLARTIGUE, Carole
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorSIRAND-PUGNET, Pascal
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorARFI, Yonathan
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorBARANOWSKI, Eric
dc.date.accessioned2024-04-11T10:06:40Z
dc.date.available2024-04-11T10:06:40Z
dc.date.conference2023-07-16
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197557
dc.description.abstractEnTo meet the demographic pressure, the livestock industry must intensify production while striving for sustainable management. With the emergence and re-emergence of infectious diseases, including those caused by mycoplasmas, improving animal health and welfare is a key aspect of this challenge. While antibiotic treatments are facing an alarming rate of resistance, vaccines are only available for a very limited number of species and often provide insufficient protection. The RAMbo-V project intends to build on advances in bacterial genome engineering to pave the way for the development of synthetic vaccines against Mycoplasma bovis, a livestock pathogen associated with emerging episodes worldwide. This will be done by adapting and improving genetic tools recently developed in other mycoplasma species and using a high-throughput strategy for large-scale mapping of highly conserved antibody epitopes in the M. bovis pan-proteome. To engineer an avirulent vaccine chassis and secure its genetic stability, virulence factors non-essential for laboratory growth will be deleted from the M. bovis genome together with mobile genetic elements and chromosomal regions contributing to horizontal gene flows. Finally, the surface of M. bovis will be redesigned to allow optimal expression of selected epitopes through the use of a transmembrane carrier and the locking of surface variation mechanisms. By exploring an innovative vaccine strategy, RAMbo-V will have a positive impact on animal production and its dependence on antimicrobials. RAMbo-V will thus contribute to the development of sustainable food systems that manage demographic pressure with environmental, societal, and ethical challenges.
dc.description.sponsorshipApproche rationnelle d'un vaccin Mycoplasma bovis - ANR-21-CE35-0008
dc.language.isoen
dc.title.enRAMbo-V project: paving the way for the development of synthetic vaccines against Mycoplasma bovis
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)
dc.subject.halSciences du Vivant [q-bio]
bordeaux.hal.laboratoriesBiologie du Fruit & Pathologie (BFP) - UMR 1332*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
bordeaux.conference.title24th Congress of the International Organization for Mycoplasmology
bordeaux.countryJP
bordeaux.conference.cityOsaka
hal.identifierhal-04343130
hal.version1
hal.proceedingsnon
hal.conference.end2023-07-20
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04343130v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=RIDEAU,%20Fabien&HOGAN,%20Patrick&DERRICHE,%20M%E2%80%99hamed&GOURGUES,%20Geraldine&POT,%20Gwendoline&rft.genre=conference


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