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Phase Transfer and DNA Functionalization of Quantum Dots Using an Easy-to-Prepare, Low-Cost Zwitterionic Polymer

dc.rights.licenseopen
hal.structure.identifierBoston University [Boston] [BU]
hal.structure.identifierDivision of Materials Science and Engineering
dc.contributor.authorCHERN, Margaret
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierDepartment of Chemistry, Boston University
dc.contributor.authorGRAZON, Chloé
hal.structure.identifierBoston University [Boston] [BU]
hal.structure.identifierDivision of Materials Science and Engineering
hal.structure.identifierDepartment of Biomedical Engineering [Boston]
dc.contributor.authorDENNIS, Allison
dc.contributor.editorFontes A.
dc.contributor.editorSantos B.
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.isbn978-1-0716-0462-5
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19700
dc.description.abstractEnSmall, stable, and bright quantum dots (QDs) are of interest in many biosensing and biomedical imaging applications, but current methodologies for obtaining these characteristics can be highly specialized or expensive. We describe a straightforward, low-cost protocol for functionalizing poly(isobutylene-alt-maleic anhydride) (PIMA) with moieties that anchor to the QD surface (histamine), impart hydrophilicity [(2-aminoethyl)trimethylammonium chloride (Me3N+-NH2)], and provide a platform for biofunctionalization via click chemistry (dibenzocyclooctyne (DBCO)). Guidelines to successfully use this polymer for QD ligand exchange are presented, and an example of biofunctionalization with DNA is shown. Stable QD–DNA conjugates are obtained with high yield and without requiring additional purification steps.
dc.language.isoen
dc.publisherHumana, New York, NY
dc.source.titleQuantum Dots
dc.subject.enDNA labeling
dc.subject.enCopper-free click chemistry
dc.subject.enBiofunctionalization
dc.subject.enNanoparticle
dc.subject.enCarboxybetaine
dc.subject.enPoly(isobutylene-alt-maleic anhydride)—PIMA
dc.title.enPhase Transfer and DNA Functionalization of Quantum Dots Using an Easy-to-Prepare, Low-Cost Zwitterionic Polymer
dc.typeChapitre d'ouvrage
dc.identifier.doi10.1007/978-1-0716-0463-2_7
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.description.sponsorshipEuropeA Wearable Sensor for Hormones Based on a Native Microbial Sensing
bordeaux.page125-139
bordeaux.volume2135
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
hal.identifierhal-02533646
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02533646v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Quantum%20Dots&rft.date=2020&rft.volume=2135&rft.spage=125-139&rft.epage=125-139&rft.au=CHERN,%20Margaret&GRAZON,%20Chlo%C3%A9&DENNIS,%20Allison&rft.isbn=978-1-0716-0462-5&rft.genre=unknown


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