Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
dc.contributor.author | NGUYEN, Michel | |
hal.structure.identifier | Laboratoire de Chimie Physique Macromoléculaire [LCPM] | |
dc.contributor.author | FERJI, Khalid | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | BONDUELLE, Colin
IDREF: 134527046 | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19662 | |
dc.description.abstractEn | Nucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate N-carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were able to spontaneously form nanoobjects in aqueous solutions avoiding a pre-solubilization step with an organic solvent. Upon self-assembly, light scattering measurements and transmission electron microscopy (TEM) revealed the impact of the architecture (diblock versus triblock) on the morphology of the resulted nanoassemblies. Interestingly, the nucleobase-containing nanoobjects displayed free thymine units in the shell that were found available for further DNA-binding. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.rights.uri | http://creativecommons.org/licenses/by/ | |
dc.subject.en | sequential ring-opening polymerization | |
dc.subject.en | amphiphilic polypeptide | |
dc.subject.en | nucleobase | |
dc.subject.en | spontaneous self-assembly | |
dc.subject.en | DNA binding | |
dc.title.en | Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly | |
dc.type | Article de revue | |
dc.identifier.doi | 10.3390/polym12061357 | |
dc.subject.hal | Chimie/Polymères | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire | |
bordeaux.page | 1357 | |
bordeaux.volume | 12 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 6 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02876032 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02876032v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2020&rft.volume=12&rft.issue=6&rft.spage=1357&rft.epage=1357&rft.eissn=2073-4360&rft.issn=2073-4360&rft.au=NGUYEN,%20Michel&FERJI,%20Khalid&LECOMMANDOUX,%20Sebastien&BONDUELLE,%20Colin&rft.genre=article |
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