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Hyaluronic acid presentation at the surface of self‐assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor

dc.rights.licenseopen
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorDUAN, Haohao
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorDONOVAN, Mark
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorHERNANDEZ, Franck
hal.structure.identifierARN : régulations naturelle et artificielle
dc.contributor.authorDI PRIMO, Carmelo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorSCHULTZE, Xavier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn1433-7851
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19650
dc.description.abstractEnIn this study, an original method of macromolecular design was used to develop a hyaluronidase‐1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). HA‐based nanoparticles (HA‐NP) were obtained by copolymer self‐assembly and their effects on HYAL1 activity were investigated by combining different analytical tools. Compared to HA, HA‐NP exhibited an enhanced stability against HYAL1 degradation while maintaining its interaction with HA receptors CD44 and aggrecan. HA‐NP displayed a strong and selective inhibition of HYAL1 activity and retarded the hydrolysis of higher molar mass HA in solution. A co‐nanoprecipitation process was used to formulate a range of hybrid nanoparticle samples, which demonstrated the specificity and efficiency of HA‐NP in HYAL1 inhibition.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.enself-assembly
dc.subject.enSurface plasmon resonance
dc.subject.enblock copolymer
dc.subject.enhyaluronan
dc.subject.entargeting
dc.subject.enreceptor inhibition
dc.subject.enHyaluronic acid
dc.subject.enHyaluronidase
dc.subject.enPolymer nanoparticles
dc.title.enHyaluronic acid presentation at the surface of self‐assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor
dc.typeArticle de revue
dc.identifier.doi10.1002/anie.202005212
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
bordeaux.journalAngewandte Chemie International Edition
bordeaux.page13591-13596
bordeaux.volume59
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue32
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02561770
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02561770v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.date=2020&rft.volume=59&rft.issue=32&rft.spage=13591-13596&rft.epage=13591-13596&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=DUAN,%20Haohao&DONOVAN,%20Mark&HERNANDEZ,%20Franck&DI%20PRIMO,%20Carmelo&GARANGER,%20Elisabeth&rft.genre=article


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