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Thermoinduced Crystallization-Driven Self-Assembly of Bioinspired Block Copolymers in Aqueous Solution

dc.rights.licenseopen
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorWANG, Zhiwei
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorLIN, Min
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorLI, Rongye
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorSHI, Zhekun
hal.structure.identifierLawrence Berkeley National Laboratory [Berkeley] [LBNL]
dc.contributor.authorZHU, Chenhui
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorLI, Zhibo
hal.structure.identifierQingdao University of Science and Technology
dc.contributor.authorSUN, Jing
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19570
dc.description.abstractEnDelicate control over architectures via crystallization-driven self-assembly (CDSA) in aqueous solution, particularly combined with external stimuli, is rare and challenging. Here, we report a stepwise CDSA process thermally initiated from amphiphilic poly(N-allylglycine)-b-poly(N-octylglycine) (PNAG-b-PNOG) conjugated with thiol-terminated triethylene glycol monomethyl ethers ((PNAG-g-EG3)-b-PNOG) in aqueous solution. The diblock copolymers show a reversible thermoresponsive behavior with nearly identical cloud points in both heating and cooling runs. In contrast, the morphology transition of the assemblies is irreversible upon a heating–cooling cycle because of the presence of a confined domain arising from crystalline PNOG, which allows for the achievement of different nanostructured assemblies by the same polymer. We demonstrated that the thermoresponsive property of PNAG-g-EG3 initiates assembly kinetically that is subsequently promoted by crystallization of PNOG thermodynamically. The irreversible morphology transition behavior provides a convenient platform for comparing the cellular uptake efficiency of nanostructured assemblies with various morphologies that are otherwise similar.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enMorphology
dc.subject.enCrystallization
dc.subject.enSolution chemistry
dc.subject.enCopolymers
dc.subject.enTransmission electron microscopy
dc.title.enThermoinduced Crystallization-Driven Self-Assembly of Bioinspired Block Copolymers in Aqueous Solution
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.biomac.0c00844
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalBiomacromolecules
bordeaux.page3411-3419
bordeaux.volume21
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue8
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02934927
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02934927v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2020&rft.volume=21&rft.issue=8&rft.spage=3411-3419&rft.epage=3411-3419&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=WANG,%20Zhiwei&LIN,%20Min&BONDUELLE,%20Colin&LI,%20Rongye&SHI,%20Zhekun&rft.genre=article


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