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Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

dc.rights.licenseopen
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
hal.structure.identifierArdena
dc.contributor.authorBRESSELEERS, Jaleesa
hal.structure.identifierDepartment of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences [UIPS]
hal.structure.identifierUniversiteit Utrecht / Utrecht University [Utrecht]
dc.contributor.authorBAGHERI, Mahsa
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLEBLEU, Coralie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorPIJPERS, Imke A. B.
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorMASON, Alexander F.
hal.structure.identifierArdena
dc.contributor.authorMEEUWISSEN, Silvie
hal.structure.identifierDepartment of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences [UIPS]
hal.structure.identifierUniversiteit Utrecht / Utrecht University [Utrecht]
dc.contributor.authorNOSTRUM, Cornelus F. Van
hal.structure.identifierDepartment of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences [UIPS]
hal.structure.identifierUniversiteit Utrecht / Utrecht University [Utrecht]
dc.contributor.authorHENNINK, Wim E.
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorHEST, Jan C. M. Van
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn2073-4360
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19550
dc.description.abstractEnThe careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.ensize control
dc.subject.ennanoprecipitation
dc.subject.ennanoparticles
dc.subject.enmicrofluidics
dc.subject.enblock copolymers
dc.subject.enmicelles
dc.subject.enpolymersomes
dc.subject.enHPMA
dc.subject.enmicromixer
dc.title.enTuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics
dc.typeArticle de revue
dc.identifier.doi10.3390/polym12112572
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.description.sponsorshipEuropeNanomedicine: an integrative approach
bordeaux.journalPolymers
bordeaux.page2572
bordeaux.volume12
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue11
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02992864
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02992864v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymers&rft.date=2020&rft.volume=12&rft.issue=11&rft.spage=2572&rft.epage=2572&rft.eissn=2073-4360&rft.issn=2073-4360&rft.au=BRESSELEERS,%20Jaleesa&BAGHERI,%20Mahsa&LEBLEU,%20Coralie&LECOMMANDOUX,%20Sebastien&SANDRE,%20Olivier&rft.genre=article


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