Dynamical modeling of tissue electroporation
Idioma
en
Article de revue
Este ítem está publicado en
Bioelectrochemistry. 2018-03, vol. 119, p. 98 - 110
Elsevier
Resumen en inglés
In this paper, we propose a new dynamical model of tissue electroporation. The model is based on equivalent circuit approach at the tissue. Considering two current densities from cells and extracellular matrix, we identify ...Leer más >
In this paper, we propose a new dynamical model of tissue electroporation. The model is based on equivalent circuit approach at the tissue. Considering two current densities from cells and extracellular matrix, we identify the macroscopic homogenised contribution of the cell membranes. Our approach makes it possible to define a macroscopic homogenised electric field and a macroscopic homogenised transmembrane potential. This provides a direct link between the cell scale electroporation models and the tissue models. Finite element method adapted to the new non-linear model of tissue electroporation is used to compare experiments with simulations. Adapting the phenomenological electroporation model of Leguèbe et al. to the tissue scale, we calibrate the tissue model with experimental data. This makes two steps appear in the tissue electroporation process, as for cells. The new insight of the model lies in the well-established equivalent circuit approach to provide a homogenised version of cell scale models. Our approach is tightly linked to numerical homogenisation strategies adapted to bioelectrical tissue modeling.< Leer menos
Palabras clave en inglés
theory of pores
phenomenological modeling
electric field
biological tissue
Electroporation
Proyecto ANR
Physique, Radiobiologie, Imagerie Médicale et Simulation - ANR-11-LABX-0063
Orígen
Importado de HalCentros de investigación