Monitoring of Serum Potassium and Calcium Levels in End-Stage Renal Disease Patients by ECG Depolarization Morphology Analysis
BUKHARI, Hassaan
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
SÁNCHEZ, Carlos
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
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Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
BUKHARI, Hassaan
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
SÁNCHEZ, Carlos
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
LAGUNA, Pablo
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
PUEYO, Esther
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
< Réduire
Aragón Institute of Engineering Research [Zaragoza] [I3A]
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
Langue
en
Article de revue
Ce document a été publié dans
Sensors. 2022-04-12, vol. 22, n° 8, p. 2951
MDPI
Résumé en anglais
Objective: Non-invasive estimation of serum potassium, [K + ], and calcium, [Ca 2+ ], can help to prevent life-threatening ventricular arrhythmias in patients with advanced renal disease, but current methods for estimation ...Lire la suite >
Objective: Non-invasive estimation of serum potassium, [K + ], and calcium, [Ca 2+ ], can help to prevent life-threatening ventricular arrhythmias in patients with advanced renal disease, but current methods for estimation of electrolyte levels have limitations. We aimed to develop new markers based on the morphology of the QRS complex of the electrocardiogram (ECG). Methods: ECG recordings from 29 patients undergoing hemodialysis (HD) were processed. Mean warped QRS complexes were computed in two-minute windows at the start of an HD session, at the end of each HD hour and 48 h after it. We quantified QRS width, amplitude and the proposed QRS morphology-based markers that were computed by warping techniques. Reference [K + ] and [Ca 2+ ] were determined from blood samples acquired at the time points where the markers were estimated. Linear regression models were used to estimate electrolyte levels from the QRS markers individually and in combination with T wave morphology markers. Leave-one-out cross-validation was used to assess the performance of the estimators. Results: All markers, except for QRS width, strongly correlated with [K + ] (median Pearson correlation coefficients, r, ranging from 0.81 to 0.87) and with [Ca 2+ ] (r ranging from 0.61 to 0.76). QRS morphology markers showed very low sensitivity to heart rate (HR). Actual and estimated serum electrolyte levels differed, on average, by less than 0.035 mM (relative error of 0.018) for [K + ] and 0.010 mM (relative error of 0.004) for [Ca 2+ ] when patient-specific multivariable estimators combining QRS and T wave markers were used. Conclusion: QRS morphological markers allow non-invasive estimation of [K + ] and [Ca 2+ ] with low sensitivity to HR. The estimation performance is improved when multivariable models, including T wave markers, are considered. Significance: Markers based on the QRS complex of the ECG could contribute to non-invasive monitoring of serum electrolyte levels and arrhythmia risk prediction in patients with renal disease.< Réduire
Mots clés en anglais
electrocardiogram
QRS complex morphology
T wave morphology
potassium estimation
calcium estimation
hemodialysis
time warping
regression
Projet Européen
Personalised In-Silico Cardiology
Project ANR
L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
Origine
Importé de halUnités de recherche