This paper is concerned with quantitative estimates for the Navier-Stokes equations. First we investigate the relation of quantitative bounds to the behaviour of critical norms near a potential singularity with Type I bound $\|u\|_{L^{\infty}_{t}L^{3,\infty}_{x}}\leq M$. Namely, we show that if $T^*$ is a first blow-up time and $(0,T^*)$ is a singular point then $$\|u(\cdot,t)\|_{L^{3}(B_{0}(R))}\geq C(M)\log\Big(\frac{1}{T^*-t}\Big),\,\,\,\,\,\,R=O((T^*-t)^{\frac{1}{2}-}).$$ We demonstrate that this potential blow-up rate is optimal for a certain class of potential non-zero backward discretely self-similar solutions. Second, we quantify the result of Seregin (2012), which says that if $u$ is a smooth finite-energy solution to the Navier-Stokes equations on $\mathbb{R}^3\times (0,1)$ with $$\sup_{n}\|u(\cdot,t_{(n)})\|_{L^{3}(\mathbb{R}^3)}<\infty\,\,\,\textrm{and}\,\,\,t_{(n)}\uparrow 1,$$ then $u$ does not blow-up at $t=1$. To prove our results we develop a new strategy for proving quantitative bounds for the Navier-Stokes equations. This hinges on local-in-space smoothing results (near the initial time) established by Jia and \v{S}ver\'{a}k (2014), together with quantitative arguments using Carleman inequalities given by Tao (2019).< Leer menos