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Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

dc.rights.licenseopenen_US
dc.contributor.authorMAROTO, Irene B.
dc.contributor.authorCOSTAS-INSUA, Carlos
dc.contributor.authorBERTHOUX, Coralie
dc.contributor.authorMORENO, Estefania
dc.contributor.authorRUIZ-CALVO, Andrea
dc.contributor.authorMONTERO-FERNÁNDEZ, Carlos
dc.contributor.authorMACÍAS-CAMERO, Andrea
dc.contributor.authorMARTIN, Ricardo
dc.contributor.authorGARCIA-FONT, Nuria
dc.contributor.authorSANCHEZ-PRIETO, Jose
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorCANELA, Enrice I.
dc.contributor.authorCASADO, Vicent
dc.contributor.authorGALVE-ROPERH, Ismael
dc.contributor.authorNÚÑEZ, Angel
dc.contributor.authorFERNÁNDEZ DE SEVILLA, David
dc.contributor.authorRODRIGUEZ-CRESPO, Ignacio
dc.contributor.authorCASTILLO, Pablo E.
dc.contributor.authorGUZMÁN, Manuel
dc.date.accessioned2024-03-27T09:27:36Z
dc.date.available2024-03-27T09:27:36Z
dc.date.issued2023-04-21
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/189000
dc.description.abstractEnThe type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R with various intracellular proteins is thought to alter receptor signaling, the identity and role of these proteins are poorly understood. Using a high-throughput proteomic analysis complemented with an array of in vitro and in vivo approaches in the mouse brain, we report that the C-terminal, intracellular domain of CB1R interacts specifically with growth-associated protein of 43 kDa (GAP43). The CB1R-GAP43 interaction occurs selectively at mossy cell axon boutons, which establish excitatory synapses with dentate granule cells in the hippocampus. This interaction impairs CB1R-mediated suppression of mossy cell to granule cell transmission, thereby inhibiting cannabinoid-mediated anti-convulsant activity in mice. Thus, GAP43 acts as a synapse type-specific regulatory partner of CB1R that hampers CB1R-mediated effects on hippocampal circuit function. © 2023, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enControl of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-023-38026-2en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37085487en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page2303en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinisterio de Ciencia e Innovaciónen_US
bordeaux.identifier.funderIDMinisterio de Universidadesen_US
hal.identifierhal-04522914
hal.version1
hal.date.transferred2024-03-27T09:27:40Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2023-04-21&rft.volume=14&rft.issue=1&rft.spage=2303&rft.epage=2303&rft.au=MAROTO,%20Irene%20B.&COSTAS-INSUA,%20Carlos&BERTHOUX,%20Coralie&MORENO,%20Estefania&RUIZ-CALVO,%20Andrea&rft.genre=article


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