Afficher la notice abrégée

dc.rights.licenseopenen_US
dc.contributor.authorSEPÚLVEDA, Carlos
dc.contributor.authorRODRÍGUEZ, Juan Manuel
dc.contributor.authorMONSALVES-ÁLVAREZ, Matias
dc.contributor.authorDONOSO-BARRAZA, Camila
dc.contributor.authorPINO-DE LA FUENTE, Francisco
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMATIAS, Isabelle
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLESTE-LASSERRE, Thierry
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorZIZZARI, Philippe
dc.contributor.authorMORSELLI, Eugenia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
dc.contributor.authorLLANOS, Miguel
dc.contributor.authorTRONCOSO, Rodrigo
dc.date.accessioned2024-03-27T08:44:36Z
dc.date.available2024-03-27T08:44:36Z
dc.date.issued2023-03-25
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188996
dc.description.abstractEnThe endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise, autophagy is involved in several cellular processes. It is required for the normal development of muscle mass and metabolism, and its deregulation is associated with diseases. It is known that the CB1 regulates signaling pathways that control autophagy, however, it is currently unknown whether the ECS could regulate autophagy in the skeletal muscle of obese mice. This study aimed to investigate the role of the CB1 in regulating autophagy in skeletal muscle. We found concomitant deregulation in the ECS and autophagy markers in high-fat diet-induced obesity. In obese CB1-KO mice, the autophagy-associated protein LC3 II does not accumulate when mTOR and AMPK phosphorylation levels do not change. Acute inhibition of the CB1 with JD-5037 decreased LC3 II protein accumulation and autophagic flux. Our results suggest that the CB1 regulates autophagy in the tibialis anterior skeletal muscle in both lean and obese mice. © 2023, The Author(s).
dc.description.sponsorshipLa signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métaboliqueen_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAutophagy
dc.subject.enEndocannabinoid receptor
dc.subject.enHigh-fat diet
dc.subject.enSkeletal muscle
dc.title.enThe CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
dc.title.alternativeBiol Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s40659-023-00426-5en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36964619en_US
bordeaux.journalBiological Researchen_US
bordeaux.page14en_US
bordeaux.volume56en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgencia Nacional de Investigación y Desarrolloen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.identifierhal-04522792
hal.version1
hal.date.transferred2024-03-27T08:44:40Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological%20Research&rft.date=2023-03-25&rft.volume=56&rft.issue=1&rft.spage=14&rft.epage=14&rft.au=SEP%C3%9ALVEDA,%20Carlos&RODR%C3%8DGUEZ,%20Juan%20Manuel&MONSALVES-%C3%81LVAREZ,%20Matias&DONOSO-BARRAZA,%20Camila&PINO-DE%20LA%20FUENTE,%20Francisco&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée