Acquired haemophilia A in paediatric patients: A retrospective French cohort of eight cases.
MOUTHON, Paul
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
GUY, Alexandre
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
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Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
MOUTHON, Paul
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
GUY, Alexandre
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
< Réduire
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac
Langue
EN
Article de revue
Ce document a été publié dans
British Journal of Haematology. 2024-02-01, vol. 204, n° 2, p. 606-611
Résumé en anglais
Acquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new-onset haemorrhagic symptoms associated with a dramatic decrease in factor VIII levels and an anti-factor VIII neutralising autoantibody ...Lire la suite >
Acquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new-onset haemorrhagic symptoms associated with a dramatic decrease in factor VIII levels and an anti-factor VIII neutralising autoantibody concentration >0.6 Bethesda units. Elderly people are often affected, whereas children are rarely affected; the paediatric incidence reported in the literature is about 0.045 case/million/year. For some time, the paediatric standard of care has been that for adults, but clinicians have often reported poor outcomes. Here, we describe the largest retrospective paediatric AHA cohort assembled to date, including eight patients diagnosed in France from 2000 to 2020.< Réduire
Mots clés en anglais
Adult
Humans
Child
Aged
Hemophilia A
Retrospective Studies
Hemorrhage
Autoantibodies
Factor VIII
Unités de recherche