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Brain artery diameters and risk of dementia and stroke

dc.rights.licenseopenen_US
dc.contributor.authorMELGAREJO, Jesus D
dc.contributor.authorGUREL, Kursat
dc.contributor.authorCOMPTON, Cassidy Rose
dc.contributor.authorLIU, Minghua
dc.contributor.authorGUZMAN, Vanessa
dc.contributor.authorASSURAS, Stephanie
dc.contributor.authorLEVIN, Bonnie E
dc.contributor.authorELKIND, Mitchell S V
dc.contributor.authorIKRAM, M Kamran
dc.contributor.authorKAVOUSI, Maryam
dc.contributor.authorIKRAM, M Arfan
dc.contributor.authorWRIGHT, Clinton
dc.contributor.authorCRIVELLO, Fabrice
dc.contributor.authorLAURENT, Alexandre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorVERNOOIJ, Meike W
dc.contributor.authorRUNDEK, Tatjana
dc.contributor.authorZHANG, Zhen-Yu
dc.contributor.authorBOS, Daniel
dc.contributor.authorGUTIERREZ, Jose
dc.date.accessioned2024-03-14T14:37:22Z
dc.date.available2024-03-14T14:37:22Z
dc.date.issued2024-02-08
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188800
dc.description.abstractEnINTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images. METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
dc.language.isoENen_US
dc.subject.enBrain artery diameter
dc.subject.enDementia
dc.subject.enMagnetic resonance imaging
dc.subject.enPopulation-based science
dc.subject.enStroke
dc.title.enBrain artery diameters and risk of dementia and stroke
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.13712en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38332543en_US
bordeaux.journalAlzheimer’s and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04505022
hal.version1
hal.date.transferred2024-03-14T14:37:25Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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