MELGAREJO, Jesus D; GUREL, Kursat; COMPTON, Cassidy Rose; LIU, Minghua; GUZMAN, Vanessa; ASSURAS, Stephanie; LEVIN, Bonnie E; ELKIND, Mitchell S V; IKRAM, M Kamran; KAVOUSI, Maryam; IKRAM, M Arfan; WRIGHT, Clinton; CRIVELLO, Fabrice; LAURENT, Alexandre; TZOURIO, Christophe; VERNOOIJ, Meike W; RUNDEK, Tatjana; ZHANG, Zhen-Yu; BOS, Daniel; GUTIERREZ, Jose

doi:10.1002/alz.13712

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Alzheimer’s and Dementia. 2024-02-08

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INTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images. METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.< Réduire

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Brain artery diameter

Dementia

Magnetic resonance imaging

Population-based science

Stroke

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Brain artery diameters and risk of dementia and stroke

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